Profile

Education

Ph.D. in Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan

M.S. in Institute of Microbiology and Immunology, National Yang Ming University, Taiwan

B.S. in Department of Medical Technology National Cheng Kung University, Taiwan

Professional experience

Associate Professor (2026 ~ present) 

Department of Microbiology and Immunology,National Cheng Kung University, Taiwan

Visiting Associate Professor (2026 ~ present)

Center for Advanced Modalities and Drug Delivery System, The University of Osaka, Japan

Center for Infectious Disease Education and Research, The University of Osaka, Japan

Specially-appointed Associate Professor (2023 ~ 2025)

Center for Advanced Modalities and Drug Delivery System, The University of Osaka, Japan

Center for Infectious Disease Education and Research, The University of Osaka, Japan

Specialist (2022 ~ 2023)

Department of Microbiology and Immunology, University of California, San Francisco, USA

Associate Specialist (2018 ~ 2022)

Department of Microbiology and Immunology, University of California, San Francisco, USA

Postdoctoral Scholar (2012 ~ 2018)

Department of Microbiology and Immunology, University of California, San Francisco, USA

Professional experience

Molecular virology, vaccine development, molecular biology, medical technology

Research interest

Viruses rapidly evolve in response to environmental pressures. Our team employs directed virus evolution to investigate how viruses acquire specific functions, enabling us to manipulate viral phenotypes. We use this approach to study viral pathogenesis, identify virulence factors, and develop live-attenuated vaccines and novel antiviral strategies.

Publication

Selected papers

1. J. Hirano, T. Hayashi, K. Kitamura, Y. Nishimura, H. Shimizu, T. Okamoto, K. Okada, K. Uemura, M. T. Yeh, C. Ono, S. Taguwa, M. Muramatsu, Y. Matsuura, Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1. J. Virol. 98, e00813-24 (2024).
2. Catching A, Yeh MT, Bianco S, Capponi S, Andino R. 2023. A tradeoff between enterovirus A71 particle stability and cell entry. Nat Commun 14:7450.
3. Yeh MT, Smith M, Carlyle S, Konopka-Anstadt JL, Burns CC, Konz J, Andino R, Macadam A. 2023. Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3. Nature 619:135–142.
4. Konz JO, Schofield T, Carlyle S, Wahid R, Ansari A, Strating JRPM, Yeh MT, Manukyan H, Smits SL, Tritama E, Rahmah L, Ugiyadi D, Andino R, Laassri M, Chumakov K, Macadam A. 2021. Evaluation and validation of next-generation sequencing to support lot release for a novel type 2 oral poliovirus vaccine. Vaccine: X 8:100102.
5. Catching A, Capponi S, Yeh MT, Bianco S, Andino R. 2021. Examining the interplay between face mask usage, asymptomatic transmission, and social distancing on the spread of COVID-19. Sci Rep 11:15998.
6. Chaudhary O, Wang L, Bose D, Narayan V, Yeh MT, Carville A, Clements JD, Andino R, Kozlowski PA, Aldovini A. 2020. Comparative Evaluation of Prophylactic SIV Vaccination Modalities Administered to the Oral Cavity. AIDS Res Hum Retroviruses 36:984–997.
7. Konopka-Anstadt JL, Campagnoli R, Vincent A, Shaw J, Wei L, Wynn NT, Smithee SE, Bujaki E, Yeh MT, Laassri M, Zagorodnyaya T, Weiner AJ, Chumakov K, Andino R, Macadam A, Kew O, Burns CC. 2020. Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization. npj Vaccines 5:26.
8. Yeh MT, Bujaki E, Dolan PT, Smith M, Wahid R, Konz J, Weiner AJ, Bandyopadhyay AS, Damme PV, Coster ID, Revets H, Macadam A, Andino R. 2020. Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence. Cell Host Microbe 27:736-751.e8.
9. Yeh MT, Capponi S, Catching A, Bianco S, Andino R. 2020. Mapping Attenuation Determinants in Enterovirus-D68. Viruses 12:867
10. Tan SK, Granados AC, Bouquet J, Hoy-Schulz YE, Green L, Federman S, Stryke D, Haggerty TD, Ley C, Yeh M-T, Jannat K, Maldonado YA, Andino R, Parsonnet J, Chiu CY. 2020. Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination. Sci Rep 10:15392.
11. Taguwa S, Yeh M-T, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J. 2019. Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease. Cell Rep 26:906-920.e3.
12. Stern A, Yeh MT (Co-first author), Zinger T, Smith M, Wright C, Ling G, Nielsen R, Macadam A, Andino R. 2017. The Evolutionary Pathway to Virulence of an RNA Virus. Cell 169:35-46.e19.
13. Stern A, Bianco S, Yeh MT, Wright C, Butcher K, Tang C, Nielsen R, Andino R. 2014. Costs and Benefits of Mutational Robustness in RNA Viruses. Cell Rep 8:1026–1036.
14. Yeh M-T, Wang S-W, Yu C-K, Lin K-H, Lei H-Y, Su I-J, Wang J-R. 2011. A Single Nucleotide in Stem Loop II of 5′-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice. PLoS ONE 6:e27082.