EDUCATION

Ph.D., Experimental Pathology The University of Alabama at Birmingham, U.S.A. (1994)

B.V.M., Veterinary Medicine National Taiwan University, R.O.C. (1982)

PROFESSIONAL EXPERIENCE

Director, Animal Center, National Cheng Kung University, R.O.C. (-present)

Deputy Director, National Lab Animal Center, R.O.C (2004-

Professor, Department of Microbiology and Immunology, National Cheng Kung University, R.O.C. (2004-present )

Associate Professor, Department of Microbiology and Immunology, National Cheng Kung University, R.O.C. (1996-2004)

Instructor, Department of Microbiology and Immunology, National Cheng Kung University, R.O.C. (1994-1996)

專長學門

Laboratory animal science and medicine

Immunology

Infectious disease

研究興趣

腸病毒七十一型致病機轉：

目前已建立腸病毒口服感染小鼠的動物實驗模式 (Wang, 2001)，對於腸病毒七十一型經過腸道散佈到週邊及中樞神經以及造成肺水腫的臨床症狀之機轉也有初步的瞭解，未來將進一步探討宿主感染腸病毒後的各種免疫反應。

PUBLICATIONS

1.        Liao SC, Cheng YC, Wang YC, Wang CW,  Yang SM, Yu CK, Shieh CC,  Cheng KC, Lee MF, Chiang SR, Shieh JM, Chang MS.  IL-19 induced Th2 cytokines and was up-regulated in asthma patients.The Journal of Immunology. 2004;173(11):6712-8.

2.        Liang CC, MJ Sun, HY Lei, SH Chen, CK Yu, CC Liu, JR Wang, and TM Yeh. Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. The Journal of Medical Virology. 2004;74(4):597-603

3.        Wang YF, CT Chou, HY Lei, CC Liu, SM Wang, JJ Yan, IJ Su, JR Wang, TM Yeh SH Chen and Yu CK. A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. The Journal of Virology. 2004;78(15):7916-24.

4.        Chen YC, CK Yu, YF Wang, CC Liu, IJ Su HY Lei. A murine oral model enterovirus 71 infection model with central nervous system involvement. The Journal of General Virology. 2004;85:69-77.

5.        Wang SM, HY Lei, KJ Huang, JM Wu, JR Wang, CK Yu, IJ Su, CC Liu. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. The Journal of Infectious Diseases. 2003;188:564-570.

6.        Yu CK, CL Chen. Activation of mast cells is essential for development of house dust miteDermatophagoides farinae-induced allergic airway inflammation in mice. The Journal of Immunology. 2003;171:3808-3815.

7.        Chen CC, CT Lee, YC Liu, JY Wang, HY Lei, CK Yu. House dust mite Dermatophagoides farinaeaugments proinflammatory mediator productions and accessory function of alveolar macrophages: implications for allergic sensitization and inflammation. The Journal of Immunology. 2003;170:528-536.

8.        Yu CK, YH Liu, CL Chen. Dehydroepiandrosterone attenuates allergic airway inflammation inDermatophagoides farinae-sensitized mice. Journal of Microbiology, Immunology and Infection.2002;35:199-202.

9.        Fan JJ, CP Shao, YA Ho, CK Yu, LI Hor. Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin. Infection and Immunity.2001;69:5943-5948.

10.    Yan JJ, IJ Su, PF Chen, CC Liu, CK Yu, JR Wang. Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identification of enterovirus 71 and coxsackievirus A 16 by RT-PCR. Journal of Medical Virology. 2001;65:331-339.

11.    Wang JY, CC Shieh, CK Yu, HY Lei. Allergen-induced bronchial inflammation is associated with decreased levels of surfactant proteins A and D in a murine model of asthma. Clinical and Experimental Allergy. 2001;31:1-12.

12.    Kao ST, ST Wang, CK Yu, HY Lei, JY Wang. The effect of Chinese herbal medicine, xiao-qing-long tong (XQLT), on allergen-induced bronchial inflammation in mite-sensitized mice. Allergy. 2000;55:1-7.

13.    Yu CK, CC Chan, JR Wang, CC Liu, JJ Yan, IJ Su, HS Liu. Neutralization antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice. Journal of Biomedical Science. 2000;7:523-528.

研討會論文

1.        Chou CT, YF Wang, WT Chang, CK Yu. Point mutations on the internal ribosome entry site correlate with the virulence of enterovirus 71 in mice. Current Status & Challenge of Infectious Diseases in Asia. National Health Research Institutes and Center for Disease Control, Department of Health. 2003.Abst. p.82.

2.        Wang YH, YC Chen CK Yu, YF Wang, CC Liu, IJ Su HY Lei. A murine orally inoculated enterovirus 71 induces lesions on skin and central nervous system that mimic clinical infection. Current Status & Challenge of Infectious Diseases in Asia. National Health Research Institutes and Center for Disease Control, Department of Health. 2003. Abst. p.79.

3.        Shi GY, PH Li, CK Yu, CL Wu, AL Shiau. A three-year review of the transgenic core facility of National Cheng Kung University Laboratory Animal Center. The 14^th Annual Meeting of The Chinese Society of Laboratory Animal Science. 2002. Abst. p.35.

4.        Lee CT, CK Yu. Role of alveolar macrophage-derived pro-inflammatory mediators in T cell polarization and allergic sensitization. The Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association, ROC. 2001. Abst. p.49.

5.        Liu SL, SC Chan, WP Liaw, JC Bair, CK Yu, GY Shi. Genetic monitoring of inbred mice using restriction fragment length polymorphism analysis. The 13^th Annual Meeting of The Chinese Society of Laboratory Animal Science. 2001. Abst. p.35.

6.        Liu YC, CK Yu. Mycobacterium bovis BCG diminishes eosinophilic airway inflammation induced by repetitive challenge of Dermatophagoides farinae in mice. The Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association, ROC. 2000. Abst. p.84.

7.        Chen CL, CK Yu. House dust mite Dermatophagoides farinae abrogate the suppressive activity of alveolar macrophages on mitogen-induced T-cell proliferation and its significance in allergen sensitization. The Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association, ROC. 2000. Abst. p.39.

8.        Yu CK. Experimental enterovirus 71 infection in mice and its application in vaccine development. APEC Symposium on Enteroviral Watch Program for Children – Enterovirus 71 Epidemic in Asia Pacific Area. March 26, 2000. Chinese –Taipei.

Book chapters

1.        Yu CK. Environment protection. In A guidebook for the care and use of laboratory animals. The Chinese Society for The Laboratory Animal Science, Taiwan, ROC. p.116-119. 2001. (ISBN 957-30437-0-X)

2.        Yu CK. 1994. Possible role of fibronectin in murine respiratory mycoplasmosis of mice. Ph.D. dissertation. The University of Alabama at Birmingham. Birmingham, Alabama, USA.

3.        Lei HY, JR Lin, SS Huang, BH Fang, CK Yu. 1990. Genetic monitoring program in animal center of medical college of Cheng Kung University. p.159-179. In Proceeding the 14th Seminar on Science and Technology - Laboratory animals. Talebaski Kaikan, Japan.

指導學生

博士班:

李一平 (93至今) The enterovirus 71 battles: alpha interferon induction of the antiviral state and mechanisms of  viral evasion

王雅芳 (90至今) Pathogenesis and vaccine development of enterovirus 71

陳志隆 (88-93) Innate immunity to house dust mite allergen and its implication in allergic sensitization

碩士班:

林士超 (93至今)

吳得嘉 (93至今)

陳澤思 (92至今) EV71 induce CNS disease & pulmonary dysfunction in mice after intracranial inoculation

姚奕全 (91-93) The transmission rule of enterovirus 71 in mice

劉明亮 (91-93) The role of type I interferon in enterovirus 71 infection

周春婷 (90-92)  The toxic effect of an enterovirus 71 mutant in mice

陳美鳳 (90-92) N-acetylcysteine suppresses Dermatophagoides farine-induced pulmonary inflammation in mice

李振婷 (89-91)  一氧化氮、前列腺素E2和過氧化物在家塵蟎致敏小鼠過程中的角色

劉怡君 (88-90)  牛結核分支桿菌與呼吸道融合病毒影響塵蟎誘發小鼠的過敏反應-肺泡巨噬的鼠色

陳彥丞 (85-88)  以免疫組織染色法研究NZB/wF1小鼠的細胞激素製造細胞

陳志忠 (86-89)  家塵蟎引發小鼠肺臟過敏性反應中雙陰性T細胞激素的表現

劉怡霞 (86-88)  佐劑對由塵蟎在小鼠引發肺臟發炎反應之影響

謝哲民 (85-87)  重覆氣管內給予小鼠塵蟎引發的肺部慢性嗜酸性球發炎反應及IgE抗體

謝沛諭 (84-86)  肺部CD4^-CD8^-雙陰性T細胞在過敏性發炎反應及病毒感染的角色

研究計劃

l   Pathogenesis of EV71: CNS infection and neurogenic pulmonary edema.國科會. 2005-2008

l   基因標定轉殖小鼠之構築、培養與供應(V). 國衛院. 2004

l   利用二維電泳分析過敏小鼠支氣管肺泡沖洗液蛋白體. 國科會. 2004-2005

l   SARS的免疫致病的分子機轉─利用Spike轉殖小鼠驗証SARS引起的自體免疫反應. 國科會. 2004-2005

l   以動物模式評估益生菌或其發酵產物之抑癌功能. 經濟部(食研所). 2004.

獎勵榮譽

85年  中華民國免疫學會免疫學優秀論文獎 (J. Immunol. 1996; 156:1923)

85年  成大醫學院Paper of The Year

85年  國科會乙種研究獎勵

86年  服務十年參等服務獎章

86年  國科會甲種研究獎勵

87年  國科會甲種研究獎勵

88年  國科會甲種研究獎勵

88年  中華民國免疫學會劉文章教授學術論文獎 (J. Allergy Clin Immunol 1999; 104:228)