EDUCATION

Ph.D. (2003)  MICROBIOLOGY AND IMMUNOLOGY

University of Illinois at Chicago, USA

B.S.   (1992)  PHYSICS

Department of Physics, National Cheng Kung University

PROFESSIONAL EXPERIENCE

04/2004 – 07/2007          Postdoctoral Fellow

Stanford University

Department of Structural Biology, Stanford, CA

11/2003 - 04/2004            Postdoctoral Fellow

Molecular Biology Consortium

Advanced Light Source

Lawrence Berkeley National Lab., Berkeley, CA

08/2001 & 11/2001          Exchange Visiting Research Assistant

Groupe de cristallographie biologique

IPBS-CNRS, Toulouse, France

08/1997 - 06/1998            Teaching Assistant in Medical Microbiology lab,

                                      University of Illinois, Chicago, IL

08/1996 - 10/2003            Research Assistant

Department of Microbiology and Immunology,

University of Illinois, Chicago, IL

09/1993 - 08/1995            Research Assistant

Institute of Molecular Biology

Academia Sinica, Taipei, Taiwan

RESEARCH INTEREST

Combining molecular biology, biochemistry, biophysics and crystallography to reveal the three-dimensional structures of biological molecules, and to elucidate the fundamental structure-function relationship of the molecule.

HONORS and AWARDS

2001  Provost’s Award, University of Illinois at Chicago

MEMBERSHIP

1.        American Society for Microbiology (ASM)

2.        American Crystallographic Association (ACA)

PUBLICATIONS

1.        Lin, C.S. -H, Chao, S. -Y, Hammel, M., Nix, J. C.,  Tseng, H. -L., Tsou, C. -C., Fei, C. -H., Chiou, H. -S., Jeng, U. -S., Lin, Y. -S., Chuang, W. -J., Wu, J. -J.*, Wang, S.* (2014). Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding. PLoS ONE 9(2): e89027. (* corresponding author)

2.        Wang, C. -H, Chiang-Ni, C., Kuo, H. -T., Zheng, P. -X., Tsou, C. -C., Wang, S., Tsai, P. -J., Chuang, W. -J., Lin, Y. -S., Liu, C. -C., Wu, J. -J.* (2013). Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress. PLoS ONE 8(12): e81882.

3.        Liu, X., Hammel, M., He, Y., Tainer, J. A., Jeng, U. -S., Zhang, L., Wang, S.*, Wang, X.* (2013). Structural insights into the interaction of IL-33 with its receptors. Proc. Natl. Acad. Sci. 110(37):14918–23. (* corresponding author)

4.        Chuang, Y. -C, Wang, S., Lin, Y. -S., Chen, H. -R., Yeh, T. -M. (2013).  Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection. J. of Biomed. Sci. 2013, 20:42.

5.        Wan, S. -W., Lin, C. -F., Wang, S., Chen, Y. -H., Yeh, T. -M., Liu, H. -S., Anderson, R., Lin, Y. -S. (2013).  Current progress in dengue vaccines. J. of Biomed. Sci. 2013, 20:37.

6.        Zheng, P. -X., Chung, K. -T., Chiang-Ni, C., Wang, S., Tsai, P. -J., Chuang, W. -J., Lin, Y. -S., Liu, C. -C., Wu, J. -J. (2013).  Complete Genome Sequence of emm1 Streptococcus pyogenes A20, a Strain with an Intact Two-Component System, CovRS, Isolated from a Patient with Necrotizing Fasciitis. Genome. Announc. 1(1): e00149-12.

7.        Wan, S. -W, Lin, C. -F, Yeh, T. -M, Liu, C. -C, Liu, H. -S, Wang, S., Ling, P., Anderson, R., Lei, H. -Y., Lin, Y. -S. (2013).  Autoimmunity in dengue pathogenesis. J. Formos. Med. Assoc. 112(1):3-11. 

8.        Wang, Y. -T., Kuo, P. -H., Chiang, C. -H., Liang, J. -R., Chen, Y. -R., Wang, S., Shen, J. -C., Yuan, H. S. (2013)  The truncated C-terminal RRM domain of TDP-43 plays a key role in forming proteinaceous aggregates. J. Biol. Chem. 288(13):9049-57. 

9.        Baral, T. N., Chao, S. -Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J.*, Wang, S.* (2012). Crystal Structure of a Human Single Domain Antibody Dimer Formed through V_H-V_H Non-Covalent Interactions. PLoS ONE 7(1): e31409. (* corresponding author)

10.    Fang, Y. -T., Lin, C. -F., Liao, P. -C., Kuo, Y. -M., Wang, S., Yeh, T. -M., Shieh, C. -C., Su, I. -J., Lei, H. -Y., and Lin, Y. -S. (2010).  Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies. Mol. Immunol. 47(5), 1000-9.

11.    Wang, S., Overgard, M., Hu, Y., and McKay, D. B. (2008).  The Bacillus subtilis RNA helicase YxiN is distended in solution. Biophys. J. 94(1), L01-3. 

12.    Xu, X., Wang, S., Hu, Y., and McKay, D. B. (2007).  The periplasmic bacterial molecular chaperone SurA adapts it structure to bind peptides in alternate conformations to assert a sequence preference for aromatic residues. J. Mol. Biol. 373(2), 367-381. 

13.    Wang, S., Hu, Y., Overgard, M. and McKay, D. B. (2006).  The domain of the Bacillus subtilisDEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition fold.  RNA 12(6), 959-967. 

14.    Wang, S., Fleming, R. T., Westbrook, E. M., Matsumura, P. and McKay, D. B. (2006).  Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription. J. Mol. Biol. 355(4), 798-808.  

15.    Wang, S., Matsumura, P. and Westbrook, E. M. (2001).  Crystallization and preliminary X-ray crystallographic analysis of the FlhD/FlhC complex from Escherichia coli.  Acta Crystallogr. D57, 734-736.

16.    Yuan, H.S., Wang, S., Yang, W. Z., Finkel, S. and Johnson, R. C. (1994).  The structure of FIS mutant Pro61-Ala illustrates that the kink within long a-helix is not due to the proline residue.  J. Biol. Chem. 269, 28947-28954.

INVITED TALKS

1.        Solution Structures of the IL-33 Signaling Complex and Receptors.  2013.  The 20^th Users’ Meeting, National Synchrotron Radiation Research Center, Hsinchu, Taiwan.

2.        Small-angle X-ray Scattering studies on the IL-1 signaling complex.  2012.  The 17^th Biophysics Conference, Academia Sinica, Taipei, Taiwan.

3.        Solution architecture of Interleukin 1 signaling complex by SAXS analysis.  2011.  The 17^thUsers’ Meeting, National Synchrotron Radiation Research Center, Hsinchu, Taiwan.

4.        Solution structural studies of a flexible RNA helicase YxiN by small-angle X-ray Scattering. 2011. School of Life Sciences, Tsinghua University, Beijing, China.

5.        Solution structure of the Bacillus subtilis RNA helicase YxiN.  2010.  The 5th AOFSRR & The 22nd PAL User’s Joint Conference, Pohang, Korea.

6.        Solution structure of the Bacillus subtilis RNA helicase YxiN.  2010.  The Fourth Taiwan-Japan Workshop on Neutron and X-ray Scattering, Yilan, Taiwan.

7.        SAXS studies on the conformational changes of a FRET-based sensor protein.  2009. The 15^thUsers’ Meeting, National Synchrotron Radiation Research Center, Hsinchu, Taiwan.

CONFERENCE PRESENTATIONS

1.        Solution Structure of the IL-33 Signaling Complex.  2013.  Lecture presentation.  The Annual Meeting of the American Crystallographic Association, Honolulu, Hawaii, USA.

2.        Wang, S., Baral, T. N., Chao, S. -Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M. and Zhang, J. 2011.  Crystal Structure of a Dimeric Anti-HER2 Human Single Domain Antibody.     Poster presentation.  The XXII International Congress and General Assembly of the International Union of Crystallography, Madrid, Spain.

3.        Wang, S., Chao, S. -Y., Tsao, C. -C. and Wu, J. -J.  2010.  Crystal Structure of the Stress Response Regulator PerR from Streptococcus pyogenes.  Poster presentation.  The Annual Meeting of the American Crystallographic Association, Chicago, IL, USA.

4.        Wang, S., Overgaard, M., Hu, Y. and McKay, M.  2009.  Solution Small-Angle X-ray Scattering Studies of a Multidomain RNA Helicase, the Bacilius subtilis YxiN Protein.   Poster presentation.  XIV International Conference on Small-Angle Scattering, Oxford, UK.

PROFESSIONAL TRAININGS

1.        Workshop on Small-Angle X-ray Scattering and Diffraction Studies in Structural Biology, Stanford Synchrotron Radiation Laboratory, CA, USA, July 2006.

2.        ACA Summer Course in X-ray Crystallography, X-ray Crystallography Center, University of Georgia, Athens, GA, USA, July 2000.