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Bei-Chang Yang, Ph.D.

楊倍昌

Bei-Chang Yang, Ph.D.

Tel (Office)

886-6-235 3535 ext. 5637

Tel (Lab.)

886-6-235 3535 ext. 5636、5652

FAX

(06) 208 2705

E-mail

y1357@ mail.ncku.edu.tw

現職年月

教授(2000/08-)

Personal Web　　　　　中文版

 

 

學 歷

德國杜賓根大學自然科學博士; Doktor der Naturwissenschaft, magna cum laude (1984-1989)

中興大學植病學碩士 (1979-1981)

中興大學植病學學士 (1975-1979)

高雄中學 (1972-1975)

高雄苓雅國中 (1969-1972)

高雄成功國小 (1963-1969)

經 歷

成功大學醫學院視聽中心主任 (2003-2005)

成功大學生物科技中心執行秘書 (2002-2003)

成功大學微免所副教授 (1992-2000)

中研院研究分生所博士後副研究員 (1990-1992)

中研院研究助理 (1983-1984)

專長學門

分子生物學; 腫瘤免疫; 自體免疫; 微生物學

參與開授課程

上課資料：分子生物學; 細菌生理與遺傳; 生物科學的理則;人造抗體; 醫用微生物; 生物科學史...

研究興趣

My interest is focused on tissue specific immunity and immune dysregulation in autoimmune diseases and tumor formation.

Following are research projects currently been carried out in my laboratory:

1.     Analysis of intracellular signals leading to the expression of IL-10 and Fas-L.

2.     Searching for agents potent in manipulating the Th1/2 activities.

3.     Study on the molecular mechanism of tumor immune escape.

4.     Cell apoptosis.

5.     Fas-L on tumor formation.

6.     Extracelullar matrix and immune responses

PUBLICATIONS

完成式

 

專書：看不見的工具 (楊倍昌，成大 STM中心出版， 2008)

 

楊倍昌 (2010) 由生物實驗的設計來發現孟德爾定律的發現。(Reconsider Mendel’s principle of heredity based on the logic of experiment design) 科技、醫療與社會，第十期：193-222頁。

 

 

Some selected research papers on medical science: (* : correspondence)

  1. Chen SY, Lin JS, Lin HC, Shan YS, Cheng YJ, and Yang BC* (2015) Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor. Biochim Biophy Acta 1853:929-939.
  2. Chen SY, Lin JS, and Yang BC* (2014) Modulation of tumor cell stiffness and migration by type IV collagen through direct activation of integrin signaling pathway. Arch Biochem Biophy. 555-556:1-8.
  3. Su CC, Lin HC, Lin YP, Shan YS, and Yang BC* (2013) Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway. Cell Immunol. 281:101–110.
  4. Lin HC, Lai PY, Lin YP, Su CC, Huang JY, and Yang BC* (2012) Fas ligand enhances the malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 287:20664–20673.
  5. Shen MY, Lin YP, Yang BC, Jang YS, Chiang CK, Mettling C, Chen ZW, Sheu JR, Chang CL, Lin YL, Yang WC. (2012) Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways. Evid Based Complement Alternat Med. 2012:982396.
  6. Hwang JY, Cheng YJ, Lin YP, Lin HC, Su CC, Juliano R, and Yang BC* (2010) Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: a role of tenascin-C in immune suppression. J Immunol. 185:1450-1459.
  7. Lin YP, Cheng YJ, Huang JY, Lin HC, and Yang BC* (2010) Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T cell migration. Mol Immunol. 47:2022-2029.
  8. Lin YP, Su CC, Huang JY, Lin HC, Cheng YJ, Liu MF, Yang BC* (2009) Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis. Mol Immunol. 46:3328-3335.
  9. Cheng YJ, Lee CH, Lin YP, Hwang JY, Su CC, Chang WT, and Yang BC* (2008) Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through ERK pathway. Int J Cancer 123:1278-1285.
  10. Su CC, Lin YP, Cheng YJ, Huang JY, Chuang WJ, Shan YS, Yang BC* (2007) Phosphatidylinositol 3-kinase/akt activation by integrin-tumor matrix interaction suppresses Principal Investigator Yang, Bei-Chang (Rev. 2015/02/20) 5 Fas-mediated apoptosis in T cells. J Immunol. 179:4589-4597.
  11. Cheng YJ, Yang BC*, and Liu MY (2006) Lead increases lipopolysaccharide induced liver injury through tumor necrosis factor-overexpression by Monocytes/Macrophages: Role of protein kinase C and P42/44 mitogen-activated protein kinase. Environ Health Persp. 114:507-513.
  12. Yang BC*, Hor WS, Lin HK, Hwang JY, Lin YP, Liu MY, and Wang YJ (2003) Mediation of enhanced transcription of the IL-10 gene in T cells, upon contact with human glioma cells, by Fas signaling through a protein kinase A-independent pathway. J Immunol. 171:3947-3954.
  13. Chen YL, Chen SH, Wang JY, and Yang BC* (2003) FasL on tumor cells mediates inactivation of neutrophils. J Immunol. 171:1183-1192. Hor WS, Huang WL, Lin YS, and Yang BC (2003) Crosstalk between tumor cells and neutrophils through the Fas (APO-1, CD95)/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils. J. Leukocyte Biol. 73: 363-368.
  14. Chen YL, Wang JY, Chen SH, and Yang BC* (2002) Granulocytes mediates the Fas-L-associated apoptosis during lung metastasis of melanoma that determines the metastatic behavior. Br. J. Cancer 87:359-365.
  15. Chio CC, Wang YS, Chen YL, Lin SJ, and Yang BC* (2001) Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis, tumor infiltrating cells, and liver damage but accelerates tumor formation in nude mice. Br. J. Cancer 85:1185-1192.

 

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