EDUCATION

Aug. 1994 - May 2001, Ph.D.

Department of Immunology, Baylor College of Medicine, Houston, Texas

Dissertation: Hematopoietic progenitor kinase 1 (HPK1) in JNK and T-cell signaling

1984 – 1988, Bachelor of Science

School of Medical Technology, National Yang-Ming University, Taipei, Taiwan

EXPERIENCE

Aug. 2012 – Present: Associate professor

Department of Microbiology and Immunology, National Cheng-Kung University,

Tainan, Taiwan

Aug. 2005 – Jul. 2012: Assistant professor

Department of Microbiology and Immunology, National Cheng-Kung University,

Tainan, Taiwan

Dec. 2003 - Jul. 2005: Postdoctoral fellow

Department of Biochemistry & Molecular Biology, Baylor College of Medicine,

Houston, Texas

Research project: Proteomic and functional analysis of the TBK1-IRF3 Pathway

Advisor: Jun Qin, Ph.D.

Oct. 2002- Dec. 2003: Postdoctoral fellow

Department of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas

Research project: Her2/Neu signaling pathway and breast cancer development

Advisor: Mien-Chie Hung, Ph.D.

May 2001- Feb. 2002: Postdoctoral fellow

Department of Immunology, Baylor College of Medicine, Houston, Texas

Research project: Signal transduction by hematopoietic progenitor kinase 1 (HPK1)

Advisor: Tse-Hua Tan, Ph.D.

Major field

Immunology

Virology

Signal Transduction

Research Interests

Operations of the mammalian innate immune system.

Interactions between viruses and the host innate immune system.

BOOKS

1.          Chen K.R. and Ling P. Emerging roles of an innate immune regulator TAPE in the Toll-like receptor and RIG-I-like receptor pathways. 2015. Inflammation and Immunity in Cancer. Springer, Japan. Chapter 5: 63-74 (Review book edited by Seya, T., Matsumoto, M., Udaka, K., and Sato, N.).

2.          Ling P, and Tan TH. Signal transduction by HPK1, a mammalian STE20-related serine/threonine protein kinase (Review). Research Signpost. --, 2002: 3: P. 297-P.315. 

PUBLICATION

1.      Yao HW, Ling P, Tung YY, Hsu SM, Chen SH. 2014. In Vivo Reactivation of Latent Herpes Simplex Virus 1 in Mice Can Occur in the Brain before Occurring in the Trigeminal Ganglion. Journal of virology 88:11264-11270.

2.      Wan SW, Lin CF, Yeh TM, Liu CC, Liu HS, Wang S, Ling P, Anderson R, Lei HY, Lin YS. 2013. Autoimmunity in dengue pathogenesis. Journal of the Formosan Medical Association 112:3-11.

3.      Yao HW, Ling P, Chen SH, Tung YY, Chen SH. 2012. Factors affecting herpes simplex virus reactivation from the explanted mouse brain. Virology 433:116-123.

4.      Wang LC, Kao CM, Ling P, Su IJ, Chang TM, Chen SH. 2012. CD4 T-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads. Clinical & developmental immunology 2012:580696.

5.      Chen KR, Chang CH, Huang CY, Lin CY, Lin WY, Lo YC, Yang CY, Hsing EW, Chen LF, Shih SR, Shiau AL, Lei HY, Tan TH, Ling P. 2012. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. The Journal of biological chemistry 287:32216-32221.

6.      Lin LH, Ling P, Liu MF. 2011. The potential role of interferon-regulatory factor 7 among Taiwanese patients with systemic lupus erythematosus. The Journal of rheumatology 38:1914-1919.

7.      Chang CH, Lai LC, Cheng HC, Chen KR, Syue YZ, Lu HC, Lin WY, Chen SH, Huang HS, Shiau AL, Lei HY, Qin J, Ling P. 2011. TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways. The Journal of biological chemistry 286:7043-7051.

8.      Huang WY, Su YH, Yao HW, Ling P, Tung YY, Chen SH, Wang X, Chen SH. 2010. Beta interferon plus gamma interferon efficiently reduces acyclovir-resistant herpes simplex virus infection in mice in a T-cell-independent manner. The Journal of general virology 91:591-598.

9.      Ling P, Lu TJ, Yuan CJ, Lai MD. 2008. Biosignaling of mammalian Ste20-related kinases. Cellular signalling 20:1237-1247.

10.  Li ZH, Li CM, Ling P, Shen FH, Chen SH, Liu CC, Yu CK, Chen SH. 2008. Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication. The Journal of infectious diseases 197:854-857.

11.  Lee JC, Won SJ, Chao CL, Wu FL, Liu HS, Ling P, Lin CN, Su CL. 2008. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochemical and biophysical research communications 372:236-242.

12.  Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. 2005. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and cellular biology 25:11005-11018.

13.  Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M. 2001. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. Oncogene 20:1703-1714.

14.  Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH. 2001. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. The Journal of biological chemistry 276:18908-18914.

15.  Ito Y, Pandey P, Sathyanarayana P, Ling P, Rana A, Weichselbaum R, Tan TH, Kufe D, Kharbanda S. 2001. Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress. The Journal of biological chemistry 276:18130-18138.

16.  McAveney KM, Book ML, Ling P, Chebath J, Yu-Lee L. 2000. Association of 2',5'-oligoadenylate synthetase with the prolactin (PRL) receptor: alteration in PRL-inducible stat1 (signal transducer and activator of transcription 1) signaling to the IRF-1 (interferon-regulatory factor 1) promoter. Molecular endocrinology (Baltimore, Md.) 14:295-306.

17.  Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH. 1999. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Molecular and cellular biology 19:1359-1368.

18.  Chang KS, Lin CI, Ling P, Lin KH, Lin HC, Twu SJ. 1994. Molecular subtypes of env sequences around V3 region of human immunodeficiency virus type 1 in Taiwan. European journal of epidemiology 10:247-250.