Profile

Education

2016–2021　Ph.D. in Institute of Basic Medical Sciences of National Cheng Kung University

2012-2014　M.S. in Department of Microbiology & Immunology of National Cheng Kung University

2008–2012　B.S. in Department of Medical Biotechnology and Laboratory Science of Chang Gung University

Professional experience

Aug. 2024 – present　  Assistant Professor, Department of Immunology & Microbiology, College of Medicine, National Cheng Kung University

Aug. 2021 – Jul. 2024　Postdoctoral Research Fellow, Allergy Immunology and Microbiome Center, China Medical University Hospital

Mar. 2021 – Jul. 2021　Postdoctoral Research Fellow, Department of Pediatric, National Cheng Kung University

Feb. 2021 – Jul. 2024　Adjunct Assistant Professor, Department of Nursing, National Tainan Junior College of Nursing

Jun. 2015 – Jan. 2021　Adjunct Lecturer, Department of Nursing, National Tainan Junior College of Nursing

Specialties

Immunology, Allergic immunology, Microbiome and Probiotic in allergic disease、Microbiome research

Research interest

Microbiome plays a crucial role in immune function, with dysbiosis linked to allergic diseases, mucosal inflammation, and metabolic-related conditions. My research focuses on allergic and mucosal inflammatory diseases. Building on my previous work in developing active anti-allergy components from probiotics to improve allergic asthma and studying how environmental microbial exposure exacerbates allergic inflammation, my laboratory aims to expand into mucosal inflammation, exploring microbiome-host immune interactions.

The main research direction of my laboratory is:

1.  Investigating the mechanisms by which probiotics or beneficial commensal bacteria improve allergic and mucosal inflammatory diseases.
2.  Developing strategies to control immunometabolism for the treatment of allergic and mucosal inflammatory diseases.
3.  Using microbiome-based biomarkers for diseases and developing microbiome transplantation methods to treat allergic and mucosal inflammatory diseases.

Publication

Selected papers

1. Pei-Chi Chen, Miao-Hsi Hsieh, Wei-Leng Chen, Yu-Pu Hsia, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Shulhn-Der Wang, Xiao-Yu Liu, Jiu-Yao Wang, and Hui-Fang Kao. Moonlighting glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus gasseri inhibits keratinocyte apoptosis and skin inflammation in experimental atopic dermatitis. Asian Pac J Allergy Immunol. 2024 May 6. doi: 10.12932/AP-211123-1733. Online ahead of print.
2. Pei-Chi Chen, Han-Yin Hsu, Yi-Chu Liao, Chia-Chia Lee, Miao-Hsi, Hsieh, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, and Jiu-Yao Wang. Oral administration of Lactobacillus delbrueckii subsp. lactis LDL557 attenuates airway inflammation and changes the gut microbiota in a Der p-sensitized mouse model of allergic asthma. Asian Pac J Allergy Immunol. 2024 May 6. doi: 10.12932/AP-200823-1672. Online ahead of print.
3. Natalia Paramonova, Ilva Trapina, Brigita Gradauskiene (Sitkauskiene), Samanta Plavina, Laura Tamsauskiene, Daina Bastyte, Ingrida Rumba-Rozenfelde, Sandra Tapina, Ieva Stakaitiene, Rasa Ugenskiene, Lawrence Shih-Hsin Wu, Jiu-Yao Wang, Miao-Hsi Hsieh, Pei-Chi Chen, and Nikolajs Sjakste. Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts. Int J Mol Sci. 2024 Feb 5;25(3):1943.
4. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Jiu-Yao Wang. Trained immunity and macrophage reprogramming in allergic disorders. Cell Mol Immunol. 2023 Sep;20(9):1084-1086.
5. Po-Ting Chen, Pei-Chi Chen, Jiu-Yao Wang, Shulhn-Der Wang, Li-Jen Lin. Evaluation of You-Gui-Wan critical compounds inhibiting ALOX-5 and HDC gene expression in RBL-2H3 cells using a fractional factorial design. J Ethnopharmacol. 2023 Apr 6:305:116122.
6. Miao-Hsi Hsieh, Pei-Chi Chen, Han-Yin Hsu, Jui-Chang Liu, Yu-Sheng Ho, Yuh Jyh Lin, Chin-Wei Kuo, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Zhi-Gang Liu, Lawrence Shih-Hsin Wu, and Jiu-Yao Wang. Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease. Cell Mol Immunol. 2023 Jan;20(1):38-50.
7. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng, Jiu-Yao Wang. Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages. J Biomed Sci. 2022 Sep 29;29(1):75.
8. Tsunglin Liu, Cheng-Han Lin, Yi-Lin Chen, Shuen-Lin Jeng, Hui-Ju Tsai, Chung-Liang Ho, Wen-Shuo Kuo, Miao-Hsi Hsieh, Pei-Chi Chen, Lawrence Shih-Hsin Wu, Jiu-Yao Wang. Nasal Microbiome Change During and After Exacerbation in Asthmatic Children. Front Microbiol. 2022 Mar 4:12:833726.
9. Wen-Shuo Kuo, Yen-Sung Lin, Ping-Ching Wu, Chia-Yuan Chang, Jiu-Yao Wang, Pei-Chi Chen, Miao-Hsi Hsieh, Hui-Fang Kao, Sheng-Han Lin, Chan-Chi Chang. Two-Photon-Near Infrared-II Antimicrobial Graphene-Nanoagent for Ultraviolet-Near Infrared Imaging and Photoinactivation. Int J Mol Sci. 2022 Mar 17;23(6):3230.
10. Wen-Shuo Kuo, Ping-Ching Wu, Chi-Yao Hung, Chia-Yuan Chang, Jiu-Yao Wang, Pei-Chi Chen, Miao-Hsi Hsieh, Sheng-Han Lin, Chan-Chi Chang, Yen-Sung Lin. Nitrogen Functionalities of Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Highly Efficient Enhancement of Antimicrobial Therapy to Eliminate Methicillin-Resistant Staphylococcus aureus and Utilization as a Contrast Agent. Int J Mol Sci. 2021 Sep 7;22(18):9695.
11. Pei-Chi Chen, Yu-Ting Shao, Miao-Hsi Hsieh, Hui-Fang Kao, Wen-Shuo Kuo, Shih-Min Wang, Shun-Hua Chen, Lawrence Shih Hsin Wu, Hui-Ju Tsai and Jiu-Yao Wang. Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained immunity of macrophages. Cell Mol Immunol. 2021 Feb;18(2):472-483.
12. Hui Fang Kao, Yu-Chin Wang, Hsiu-Ying Tseng, Lawrence Shih Hsin Wu, Hui-Ju Tsai, Miao-Hsi Hsieh, Pei-Chi Chen, Wen-Shou Kuo, Li-Fan Liu, Zhi-Gang Liu and Jiu-Yao Wang. Goat's milk feeding enhances innate and adaptive immunities and alleviates allergen-induced airway inflammation in offspring mice. Front Immunol. 2020 Feb 18:11:184.
13. Miao-Hsi Hsieh, Ren-Long Jan, Shih-Hsin Lawrence Wu, Pei-Chi Chen, Hui-Fang Kao, Wen-Shuo Kuo, Jiu-Yao Wang. Lactobacillus gasseri attenuates allergic airway inflammation through PPARγ activation in dendritic cells. J Mol Med (Berl). 2018 Jan;96(1):39-51.
14. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Hui-Fan Kao, Chih-Li Hsu, and Jiu-Yao Wang. Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis. J Allergy Clin Immunol. 2017 Oct;140(4):1146-1149.e8.
15. Wen-Shuo Kuo, Hua-Han Chen, Shih-Yao Chen, Chia-Yuan Chang, Pei-Chi Chen, Yung-I Hou, Yu-Ting Shao, Hui-Fang Kao, Chih-Li Lilian Hsu, Yi-Chun Chen, Shean-Jen Chen, Shang-Rung Wu, Jiu-Yao Wang. Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bio-imaging. Biomaterials. 2017 Mar:120:185-194.