陳佩琪老師
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陳佩琪 |
Pei-Chi Chen, Ph.D. |
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辦公室電話 |
886-6-235 3535 ext. 5629 |
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實驗室電話 |
886-6-235 3535 ext. 5623 | |
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傳真 |
(06) 208 2705 |
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電子郵件 |
chenn9143@gs.ncku.edu.tw |
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現職年月 |
助理教授 (2024/08-) |
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個人網頁，請按此連結 English |
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小檔案
學 歷
國立成功大學基礎醫學研究所博士 (2016-2021)
國立成功大學微生物及免疫學研究所碩士 (2012-2014)
長庚大學醫學生物技術暨檢驗學系學士 (2008-2012)
經 歷
國立成功大學微生物及免疫學研究所助理教授(2024/08-present)
中國醫藥大學附設醫院過敏免疫及微菌叢研究中心博士後研究員(2021/08-2024/07)
國立成功大學小兒科博士後研究員(2021/03-2021/07)
國立臺南護理專科學校護理科兼任助理教授 (2021/02-2024/07)
國立臺南護理專科學校護理科兼任講師(2015/06-2021/01)
專長學門
免疫學、過敏免疫學、微菌叢及益生菌在過敏性疾病的作用、微菌叢研究
研究興趣
微菌叢在人體免疫功能中扮演重要角色，過敏性疾病和黏膜發炎等代謝相關疾病的免疫功能異常通常與腸道微生物的紊亂有關。因此，探討微菌叢如何調控黏膜免疫發炎已成為預防和治療這些疾病的重點研究課題。本實驗室專注於過敏及黏膜發炎疾病，基於過去開發益生菌蛋白改善過敏性氣喘及研究環境微生物暴露引發過敏性發炎加劇的成果，進一步擴展至黏膜發炎疾病，探討微菌叢與宿主黏膜免疫的相互作用。
實驗室主要研究方向：
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研究益生菌或有益共生菌在改善過敏及黏膜發炎疾病中的作用機制。
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開發控制免疫代謝的策略，以應用於治療過敏及黏膜發炎疾病。
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將微菌叢的變化作為疾病的生物標記，並開發微菌叢移植治療過敏及黏膜發炎疾病的方法。
PUBLICATION
Refereed papers
1. Pei-Chi Chen, Miao-Hsi Hsieh, Wei-Leng Chen, Yu-Pu Hsia, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Shulhn-Der Wang, Xiao-Yu Liu, Jiu-Yao Wang, and Hui-Fang Kao. Moonlighting glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus gasseri inhibits keratinocyte apoptosis and skin inflammation in experimental atopic dermatitis. Asian Pac J Allergy Immunol. 2024 May 6. doi: 10.12932/AP-211123-1733. Online ahead of print.
2. Pei-Chi Chen, Han-Yin Hsu, Yi-Chu Liao, Chia-Chia Lee, Miao-Hsi, Hsieh, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, and Jiu-Yao Wang. Oral administration of Lactobacillus delbrueckii subsp. lactis LDL557 attenuates airway inflammation and changes the gut microbiota in a Der p-sensitized mouse model of allergic asthma. Asian Pac J Allergy Immunol. 2024 May 6. doi: 10.12932/AP-200823-1672. Online ahead of print.
3. Natalia Paramonova, Ilva Trapina, Brigita Gradauskiene (Sitkauskiene), Samanta Plavina, Laura Tamsauskiene, Daina Bastyte, Ingrida Rumba-Rozenfelde, Sandra Tapina, Ieva Stakaitiene, Rasa Ugenskiene, Lawrence Shih-Hsin Wu, Jiu-Yao Wang, Miao-Hsi Hsieh, Pei-Chi Chen, and Nikolajs Sjakste. Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts. Int J Mol Sci. 2024 Feb 5;25(3):1943.
4. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Jiu-Yao Wang. Trained immunity and macrophage reprogramming in allergic disorders. Cell Mol Immunol. 2023 Sep;20(9):1084-1086.
5. Po-Ting Chen, Pei-Chi Chen, Jiu-Yao Wang, Shulhn-Der Wang, Li-Jen Lin. Evaluation of You-Gui-Wan critical compounds inhibiting ALOX-5 and HDC gene expression in RBL-2H3 cells using a fractional factorial design. J Ethnopharmacol. 2023 Apr 6:305:116122.
6. Miao-Hsi Hsieh, Pei-Chi Chen, Han-Yin Hsu, Jui-Chang Liu, Yu-Sheng Ho, Yuh Jyh Lin, Chin-Wei Kuo, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Zhi-Gang Liu, Lawrence Shih-Hsin Wu, and Jiu-Yao Wang. Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease. Cell Mol Immunol. 2023 Jan;20(1):38-50.
7. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng, Jiu-Yao Wang. Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages. J Biomed Sci. 2022 Sep 29;29(1):75.
8. Tsunglin Liu, Cheng-Han Lin, Yi-Lin Chen, Shuen-Lin Jeng, Hui-Ju Tsai, Chung-Liang Ho, Wen-Shuo Kuo, Miao-Hsi Hsieh, Pei-Chi Chen, Lawrence Shih-Hsin Wu, Jiu-Yao Wang. Nasal Microbiome Change During and After Exacerbation in Asthmatic Children. Front Microbiol. 2022 Mar 4:12:833726.
9. Wen-Shuo Kuo, Yen-Sung Lin, Ping-Ching Wu, Chia-Yuan Chang, Jiu-Yao Wang, Pei-Chi Chen, Miao-Hsi Hsieh, Hui-Fang Kao, Sheng-Han Lin, Chan-Chi Chang. Two-Photon-Near Infrared-II Antimicrobial Graphene-Nanoagent for Ultraviolet-Near Infrared Imaging and Photoinactivation. Int J Mol Sci. 2022 Mar 17;23(6):3230.
10. Wen-Shuo Kuo, Ping-Ching Wu, Chi-Yao Hung, Chia-Yuan Chang, Jiu-Yao Wang, Pei-Chi Chen, Miao-Hsi Hsieh, Sheng-Han Lin, Chan-Chi Chang, Yen-Sung Lin. Nitrogen Functionalities of Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Highly Efficient Enhancement of Antimicrobial Therapy to Eliminate Methicillin-Resistant Staphylococcus aureus and Utilization as a Contrast Agent. Int J Mol Sci. 2021 Sep 7;22(18):9695.
11. Pei-Chi Chen, Yu-Ting Shao, Miao-Hsi Hsieh, Hui-Fang Kao, Wen-Shuo Kuo, Shih-Min Wang, Shun-Hua Chen, Lawrence Shih Hsin Wu, Hui-Ju Tsai and Jiu-Yao Wang. Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained immunity of macrophages. Cell Mol Immunol. 2021 Feb;18(2):472-483.
12. Hui Fang Kao, Yu-Chin Wang, Hsiu-Ying Tseng, Lawrence Shih Hsin Wu, Hui-Ju Tsai, Miao-Hsi Hsieh, Pei-Chi Chen, Wen-Shou Kuo, Li-Fan Liu, Zhi-Gang Liu and Jiu-Yao Wang. Goat's milk feeding enhances innate and adaptive immunities and alleviates allergen-induced airway inflammation in offspring mice. Front Immunol. 2020 Feb 18:11:184.
13. Miao-Hsi Hsieh, Ren-Long Jan, Shih-Hsin Lawrence Wu, Pei-Chi Chen, Hui-Fang Kao, Wen-Shuo Kuo, Jiu-Yao Wang. Lactobacillus gasseri attenuates allergic airway inflammation through PPARγ activation in dendritic cells. J Mol Med (Berl). 2018 Jan;96(1):39-51.
14. Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Hui-Fan Kao, Chih-Li Hsu, and Jiu-Yao Wang. Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis. J Allergy Clin Immunol. 2017 Oct;140(4):1146-1149.e8.
15. Wen-Shuo Kuo, Hua-Han Chen, Shih-Yao Chen, Chia-Yuan Chang, Pei-Chi Chen, Yung-I Hou, Yu-Ting Shao, Hui-Fang Kao, Chih-Li Lilian Hsu, Yi-Chun Chen, Shean-Jen Chen, Shang-Rung Wu, Jiu-Yao Wang. Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bio-imaging. Biomaterials. 2017 Mar:120:185-194.