台南市大學路1號, 成大醫學院;電話(公): 886-6--2353535 ext 5366; 傳真: 886-6-2766175; 
電子郵件:  wangcr@mail.ncku.edu.tw  
現職年月：教授(2010/08)

學歷:                    

       民國76年6月        醫學士          中華民國台灣大學醫學院畢業

       民國88年3月        大學院博士    日本國東京大學第三基礎醫學

                                       (病理、微生物、免疫學)畢業

現職:

       民國99年8月~    專任教授      成功大學醫學院內科學科

                              兼任教授      成功大學醫學院微免所、基醫所

榮譽:             

       民國86年4月~ 88年3月       日本國扶輪社米山獎學會獎學金

       民國97年2月~                    美國風濕病醫學會國際專科醫師

研究興趣:

          自體免疫學、 動物關節炎模型

 研究論文: (* as a correspondence)

1.          Liu MF, Chao SC, Wang CR, Lei HY. Expression of CD40 and CD40 ligand among different population within rheumatoid synovial compartment. Autoimmunity 2001;34:107-13.

2.          Shibata Y, Kamata T, Kimura M, Yamashita M, Wang CR, Murata K, Miyazaki M, Taniguchi M, Watanabe N, Nakayama T. Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J Immunol 2002;169:2134-40.

3.          Liu MF, Wang CR, Chen PC, Fung LL. Increased expression of soluble CTLA-4 molecule in patients with systemic lupus erythematosus. Scan J Immunol 2003;57:568-72.

4.          Kamata T, Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, Sugaya K, Wang CR, Taniguchi M, Nakayama T. SH2 domain containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J Clin Invest 2003;111:109-19.

5.          *Wang CR, Liu MF. CCR5 expression and MIP-1  production in CD4+ T cells regulated by CCR5 promotor polymorphism, IL-15 stimulation and engagement of CD40 with CD40 ligand in rheumatoid arthritis. Clin Exp Immunol 2003;132: 371-8.

6.          *Wang CR, Liu MF, Huang YH, Chen HC. Up-regulation of XCR-1 expression in rheumatoid joints. Rheumatology 2004;43:569-73.

7.          Liu MF, Wang CR, Fung LL. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004;59:198-202.

8.          Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, Wu CL. Thrombospondin-1 as an effective gene therapeutic Strategy in collagen-induced arthritis. Arthritis Rheum 2005;52:339-44.

9.          *Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J. Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum 2005;52:1319-24.

10.      *Wang CR, Guo HR, Liu MF. RANTES promoter polymorphism as a genetic risk factor of rheumatoid arthritis in the Chinese. Clin Exp Rheumatol 2005;23:379-84.

11.      Chen PC, liu MF, Guo HR, Liang CC, *Wang CR. Position 247 of the b2-glycoprotein I gene polymorphism in Chinese patients with antiphospholipid syndrome. Int J Rheum Dis 2005;8:188-92.

12.      Liu MF, Wang CR, Fung LL, Lin LH, Tsai CN. The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 2005;62:312-7.

13.      Tsai CY, Shiau AL, Shih-Yao Chen, Chen YH, Cheng PC, Chang MY, Chen DH, Chou CH, *Wang CR, Wu CL. Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum 2007;56:544-54.

14.      Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura MY, Kitajiama M, Kimura F, Miyazaki M, Nakayama T. Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol Immunol 2007;44:2249-56.

15.      Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT,*Wang CR, Wu CL. Prothymosin α lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol 2007;178:4688-94.

16.      *Wang CR, Chen SY, Shiau AL, Wu CL, Jou IM, Chao L, Chao J. Up-regulation of kallistatin expression in rheumatoid joints. J Rheumatol 2007;34:2171-6.

17.      Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, Chen DH, Wang CR, Shiau AL, Wu CL. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm 2007;4:713-22.

18.      Wang CR, Shiau AL, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT, Lee CH, Kuo SM, Liu MF, Jou IM, Yang CY, Shen PC, Lee HL, Wu CL. Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer. Arthritis Rheum 2008;58:1650-6.

19.      Hsieh J, Shen PC, Shiau AL, Wu CL, Lee CH, Jou IM, Wang CR, Chao J, ChaoL, Teo ML. Adenovirus-Mediated Kallistatin Gene Transfer Ameliorates Disease Progression in a Rat Model of Osteoarthritis Induced by Anterior Cruciate Ligament Transection. Hum Gene Ther 2009;20:147-58.

20.      Chen SY, Shiau AL, Shieh GS, Su CH, Lee CH, Lee HL, *Wang CR, Wu CL. Amelioration of experimental arthritis by telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts. Arthritis Rheum 2009;60:3290-302.

21.      Shiau AL, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao J, Chao L, Wu CL, Lee CH. Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin. BMC Cancer 2010;10:245.

22.      Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Wang CR, Teo ML, Wu CL. Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J Orthop Res 2010;28:1300-6.

23.      *Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH, Yo YT, Lo CW, Lin YS, Juan HY, Chen YL, Wu CL. Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis. Gene Ther 2010;17;1225-33.

24.      Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM, Lee CH, Weng CT, Shiau AL,*Wang CR. Amelioration of rat collagen-induced arthritis through CD4+ T Cells apoptosis and synovial Interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum Gene Ther 2011;22;145-54.

25.      Chen SY, Shiau AL, Li YT, Lin YS, Lee CH, Wu CL, *Wang CR. Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene. Gene Ther 2012;19:752-60.

26.      Huang YJ, Shiau AL, Chen SY, Chen YL, Wang CR, Tsai CY, Chang MY, Li YT, Leu CH, Wu CL. Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering. Eur Cell Mater 2012;23:170-81.

27.      Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL, Wu CL. Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum 2012;64:3240-5.

國際學會論文摘要:

1.          Wang CR, Liu MF, Chen PC. Regulation of chemokine receptor CCR5 on CD4 T cells and MIP-1a production and CCR5 gene polymorphism in rheumatoid arthritis. Arthritis Rheum 2001;44(Suppl):109.

2.          Wang CR, Liu MF, Chen PC, Yang CY, Wu CR. Involvement of CCR5+CD4+ T cells in a murine model of collagen-induced arthritis. Arthritis Rheum 2002;46(Suppl):258.

3.          Wang CR, Chen PC, Liu MF. CD161+ regulatory T cells in patients with rheumatoid arthritis. Arthritis Rheum 2004;50(Suppl):524.

4.          Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J. Inhibition of experimental collagen-induced arthritis in rats by adenovirus-mediated human kallistatin gene therapy. Ann Rheum Dis 2004;63(Suppl):270.

5.          Wang CR, Shiau AL, Chen SY, Lin LL, Lin PR, Jou IM, Tai MH, Wu CL. Suppression of collagen-induced arthritis by PTEN gene-mediated inhibition of angiogenesis. Arthritis Rheum 2007;56(Suppl):289.

6.          Wang CR, Shiau AL, Chen SY, Cheng ZS, Chen YL, Yang CY, Liu MF, Wu CL. Suppression of rat collagen-induced arthritis by lentiviral vector-mediated delivery of galectin-3 short hairpin RNA gene. Arthritis Rheum 2008;58(Suppl): 650.

7.          Wang CR, Shiau AL, Chen SY, Lin YS, Chen IH, Lee YT, Yo YT, Lee CH, Lee HL, Wu CL. Suppression of rat collagen-induced arthritis by lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene. Arthritis Rheum 2009;60(Suppl):453.

8.          Wang CR, Li YT, Chen SY, Shiau AL, Weng CT, Jou IM, Liu MF, Wu CL. Amelioration of collagen-induced arthritis in mice by lentivirus-mediated overexpression of 4 tandem copies of microRNA-223 target sequence. Ann Rheum Dis 2011;70(Suppl):165.

9.          Wang CR, Chen SY, Shiau AL, Li YT, Liu MF, Wu CL. Silencing intraarticular snail expression ameliorates rat collagen-induced arthritis through induction of mesenchymal-epithelial transition insynovial fibroblasts. Arthritis Rheum 2012;64(Suppl):142.

其他著作 :

1.      Wang CR. Rheumatological manifestations of human immuno- deficiency virus infection, Chapter 26, pp 323-8, Rheumatology Textbook, 2003. Edited by Rheumatology Society of R.O.C.,Taipei.

2.      Wang CR, Shiau AL, Wu CL. Targeting MIP-1a and its receptor CCR5 in rodent models of rheumatoid arthritis. Chemokines Research Trends, 2007. Edited by Grinwald LR, NOVA Publishers, NewYork.