Colony-Stimulation factor-1-Dependent Macrophages Are Responsible for IVIG Protection in Antibody-Induced Autoimmune Disease

Immunity18, 573-581 2003

Speaker : 蕭冠中                  Time : 10/15/03 ;pm 1:00~2:00

Commentator : 劉清泉醫師                    Place : Room 601

Abstract :

     The inflammation response which induced by autoantibodies is central to the pathogenesis of many autoimmune disorders. Engaging activation Fc receptor (FcR) by IgG would trigger mast cell and macrophage activation as well as neutrophil infiltration, leading to the hallmarks of an inflammatory response. These responses are balanced through the coexpression of an inhibitory receptor, FcγRIIB. In this experiment the authors set out to determine the ability of intravenous immunoglobulin¹ (IVIG) to protect susceptible animals from K/BxN serum induced arthritis and to identify the mechanism of this protection. Injection of serum from K/BxN mice² into hosts led to the deposition of immune complexes on the surface of cartilage and triggered the localized inflammation. In this paper, the authors demonstrated that IVIG is effective at protecting mice from arthritis induced by K/BxN serum and this protection is dependent on the expression of FcγRIIB. However, disease induction but not IVIG protection was observed in CSF-1-deficient mice³ in K/BxN arthritis, which suggested  that the mechanism of FcγRIIB induction requires the presence of colony-stimulating factor-1-dependent macrophage in K/BxN arthritis. Their results showed that IVIG protection is not a one step mechanism but rather a multiple step process involving both CSF-1-dependent and –independent macrophage.

1.       Samuelsson, A., Towers, T.L. & Ravetch, J.V. Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science 291, 484-6 (2001).

2.       Kouskoff, V. et al. Organ-specific disease provoked by systemic autoimmunity. Cell 87, 811-22 (1996).

3.       Bruhns, P., Samuelsson, A., Pollard, J.W. & Ravetch, J.V. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease.Immunity 18, 573-81 (2003).