何漣漪老師
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何漣漪 |
Lien-I Hor, Ph.D. |
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電子郵件 |
h061453@ mail.ncku.edu.tw |
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現職年月 |
退休，轉任兼任教師(2017-) |
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小檔案
學歷
美國哥倫比亞大學微生物哲學博士 (1986-1991)
國立臺灣大學微生物研究所理碩士(1976-1978)
國立臺灣大學動物系理學士(1971-1975)
經歷
退休，轉任兼任教師(2017-)
成功大學微免所教授(2001-2017)
成功大學微免所所長(2012-2015)
成功大學微免所副教授(1992-2001)
成功大學醫學系講師(1985-1992)
成功大學醫學系助教(1983-1985)
衛生署預防研究所技正(1978-1983)
專長學門
細菌學
細菌遺傳學
分子生物學
研究興趣
本實驗室主要研究創傷弧菌生物一型和生物二型菌株分別在人類和鰻魚的致病機制。我們運用細菌遺傳學和基因體學技術，搜尋該菌可能之毒力基因及調控毒力表現之調控子，再以分離及分析特定基因刪除突變株在實驗動物之毒力，以確認標的基因與毒力之關連，並進一步研究該基因在致病過程中所扮演之角色，藉以了解此菌在人或鰻魚造成疾病之機制。透過這些研究，我們發現由毒素所媒介之細胞毒殺性在小鼠的感染模式中，與生物一型菌株在感染部位之繁殖能力，進而與其對小鼠的毒力相關；生物二型菌株的毒素也與該菌對鰻魚之毒力相關。生物二型菌株均含有一個大約 67 kb 的質體，與此型細菌在鰻魚血液中的存活相關，而為此菌對鰻魚之毒力所必需。
PUBLICATIONS
近五年代表作 (2003-2008)
1. Chialung Li. Lien-I Hor, Zee-Feng Chang, Li-Chu Tsai, Wei-Zeng Yang, and Hanna S. Yuan. 2003. DNA binding by the periplasmic endonuclease Vvn from Vibrio vulnificus: a novel structure with an old active site. EMBO J. 22: 4014-4025
2. Chung-Yung Chen, Keh-Ming Wu, Yo-Cheng Chang, Chuan-Hsiung Chang, Hui-Chi Tsai, Tsai-Lien Liao, Yen-Ming Liu, Hsiang-Ju Chen, Arthur Bo-Ting Shen, Jian-Chiuan Li, Teh-Li Su,Chung-Ping Shao, Chung-Te Lee, Lien-I Hor, and Shih-Feng Tsai. 2003. Comparative Genome Analysis of Vibrio vulnificus, a Marine Pathogen. Genome Res. 13: 2577-2587
3. Chung-Te Lee, Carmen Amaro, Eva Sanjuán, and Lien-I Hor. 2005. Identification of DNA sequences specific for Vibrio vulnificus biotype 2 strains by suppression subtractive hybridization.Appl. Environ. Microbiol. 71:5593-5597
4. Esmeralda Valiente, Chung-Te Lee, Lien-I. Hor, Belén Fouz1 and Carmen Amaro. 2008. Role of the metalloprotease Vvp and the virulence plasmid pR99 of Vibrio vulnificus serovar E in surface colonization and fish virulence. Environ. Microbiol. 10:328-338.
5. Esmeralda Valiente, Chung-Te Lee, Jesús Lamas, Lien-I. Hor and Carmen Amaro. 2008. Role of the virulence plasmid pR99 and the metalloprotease Vvp in resistance of Vibrio vulnificusserovar E to eel innate immunity. Fish Shellfish Immunol. 24:134-141.
6. Chung-Te Lee, Carmen Amaro, Keh-Ming Wu, Esmeralda Valiente, Yi-Feng Chang, Shih-Feng Tsai, Chuan-Hsiung Chang, and Lien-I Hor,. 2008. A common virulence plasmid in biotype 2Vibrio vulnificus and its dissemination aided by a conjugal plasmid. J. Bacteriol. 190: 1638-1648.
歷年文章作品
Lee, C.-T., Chen, I.-T., Yang, Y.-T., Ko, T.-P., Huang, Y.-T., Huang, J.-Y., Huang, M.-F., Lin, S.-J., Chen, C.-Y., Lin, S.-S., Lightner, D.V., Wang, H.-C., Wang, A.H.-J., Wang, H.-C., Hor, L.-I., Lo, C.-F.
Erratum: The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (10798-10803))
2015 Proceedings of the National Academy of Sciences of the United States of America, 112 (39), pp.E5445-.
Lee, C.-T., Chen, I.-T., Yang, Y.-T., Ko, T.-P., Huang, Y.-T., Huang, J.-Y., Huang, M.-F., Lin, S.-J., Chen, C.-Y., Lin, S.-S., Lightner, D.V., Wang, H.-C., Wang, A.H.-J., Wang, H.-C., Hor, L.-I., Lo, C.-F.
The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin
2015 Proceedings of the National Academy of Sciences of the United States of America, 112 (34), pp.10798-10803.
Pajuelo, D., Lee, C.-T., Roig, F.J., Hor, L.-I., Amaro, C.
Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus
2015 Environmental Microbiology, 17 (6), pp.2076-2089.
Murciano, C., Hor, L.-I., Amaro, C.
Host-pathogen interactions in Vibrio vulnificus: Responses of monocytes and vascular endothelial cells to live bacteria
2015 Future Microbiology, 10 (4), pp.471-487.
Pajuelo, D., Lee, C.-T., Roig, F.J., Lemos, M.L., Hor, L.-I., Amaro, C.
Host-nonspecific iron acquisition systems and virulence in the zoonotic serovar of vibrio vulnificus
2014 Infection and Immunity, 82 (2), pp.731-744.
Lee, Y.-C., Hor, L.-I., Chiu, H.-Y., Lee, J.-W., Shieh, S.-J.
Prognostic factor of mortality and its clinical implications in patients with necrotizing fasciitis caused by Vibrio vulnificus
2014 European Journal of Clinical Microbiology and Infectious Diseases, 33 (6), pp.1011-1018.
Hor, L.-I., Chen, C.-L.
Cytotoxins of Vibrio vulnificus: Functions and roles in pathogenesis
2013 BioMedicine (Netherlands), 3 (1), pp.19-26.
Lee, C.-T., Pajuelo, D., Llorens, A., Chen, Y.-H., Leiro, J.M., Padrós, F., Hor, L.-I., Amaro, C.
MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor
2013 Environmental Microbiology, 15 (2), pp.419-432.
Lo, H.-R., Lin, J.-H., Chen, Y.-H., Chen, C.-L., Shao, C.-P., Lai, Y.-C., Hor, L.-I.
RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis
2011 Journal of Infectious Diseases, 203 (12), pp.1866-1874.
Shao, C.-P., Lo, H.-R., Lin, J.-H., Hor, L.-I.
Regulation of cytotoxicity by quorum-sensing signaling in vibrio vulnificus is mediated by SmcR, a repressor of hlyU
2011 Journal of Bacteriology, 193 (10), pp.2557-2565.
Hsu, F.-Y., Chou, L.-F., Hor, L.-I., Chang, H.-Y.
A human single-chain variable fragment targeting to Vibrio vulnificus RtxA toxin
2011 Journal of Microbiological Methods, 84 (1), pp.94-100.
Chuang, C.-C., Chuang, Y.-C., Chang, W.-T., Chen, C.-C., Hor, L.-I., Huang, A.-M., Choi, P.-C., Wang, C.-Y., Tseng, P.-C., Lin, C.-F.
Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection
2010 BMC Immunology, 11 (), 50 pp.-.
Liu, C.-C., Jean, J.-S., Nath, B., Lee, M.-K., Hor, L.-I., Lin, K.-H., Maity, J.P.
Geochemical characteristics of the fluids and muds from two southern Taiwan mud volcanoes: Implications for water-sediment interaction and groundwater arsenic enrichment
2009 Applied Geochemistry, 24 (9), pp.1793-1802.
Tang, P., Liu, J.-K., Chou, S.-M., Hor, L.-I., Chen, W.-J., Chen, S.C.
A proteomic analysis of Klebsiella oxytoca after exposure to succinonitrile
2008 Process Biochemistry, 43 (7), pp.753-757.
Lee, C.-T., Amaro, C., Wu, K.-M., Valiente, E., Chang, Y.-F., Tsai, S.-F., Chang, C.-H., Hor, L.-I.
A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid
2008 Journal of Bacteriology, 190 (5), pp.1638-1648.
Valiente, E., Lee, C.-T., Hor, L.-I., Fouz, B., Amaro, C.
Role of the metalloprotease Vvp and the virulence plasmid pR99 of Vibrio vulnificus serovar e in surface colonization and fish virulence
2008 Environmental Microbiology, 10 (2), pp.328-338.
Valiente, E., Lee, C.T., Lamas, J., Hor, L., Amaro, C.
Role of the virulence plasmid pR99 and the metalloprotease Vvp in resistance of Vibrio vulnificus serovar E to eel innate immunity
2008 Fish and Shellfish Immunology, 24 (1), pp.134-141.
Chuang, C.C., Wang, S.T., Chen, W.C., Chen, C.C., Hor, L.I., Chuang, Y.C.
Increases in serum macrophage migration inhibitory factor in patients with severe sepsis predict early mortality
2007 Shock, 27 (5), pp.503-506.
Chuang, C.-C., Shiesh, S.-C., Chi, C.-H., Tu, Y.-F., Hor, L.-I., Shieh, C.-C., Chen, M.-F.
Serum total antioxidant capacity reflects severity of illness in patients with severe sepsis
2006 Critical Care, 10 (1), R36 pp.-.
Tseng, C.-C., Wu, J.-J., Wang, M.-C., Hor, L.-I., Ko, Y.-H., Huang, J.-J.
Host and bacterial virulence factors predisposing to emphysematous pyelonephritis
2005 American Journal of Kidney Diseases, 46 (3), pp.432-439.
Lee, C.-T., Amaro, C., Sanjuán, E., Hor, L.-I.
Identification of DNA sequences specific for Vibrio vulnificus biotype 2 strains by suppression subtractive hybridization
2005 Applied and Environmental Microbiology, 71 (9), pp.5593-5597.
Wong, H.-C., Chen, S.-Y., Chen, M.-Y., Oliver, J.D., Hor, L.-I., Tsai, W.-C.
Pulsed-field gel electrophoresis analysis of vibrio vulnificus strains isolated from Taiwan and the United States
2004 Applied and Environmental Microbiology, 70 (9), pp.5153-5158.
Chen, C.-Y., Wu, K.-M., Chang, Y.-C., Chang, C.-H., Tsai, H.-C., Liao, T.-L., Liu, Y.-M., Chen, H.-J., Shen, A.B.-T., Li, J.-C., Su, T.-L., Shao, C.-P., Lee, C.-T., Hor, L.-I., Tsai, S.-F.
Comparative genome analysis of Vibrio vulnificus, a marine pathogen
2003 Genome Research, 13 (12), pp.2577-2587.
Lin, C.-H., Hor, L.-I., Wu, J.-Y., Chen, T.-L.
Production of nuclease in fed-batch culture of recombinant Escherichia coli
2003 Journal of the Chinese Institute of Chemical Engineers, 34 (5), pp.507-511.
Li, C.-L., Hor, L.-I., Chang, Z.-F., Tsai, L.-C., Yang, W.-Z., Yuan, H.S.
DNA binding and cleavage by the periplasmic nuclease Vvn: A novel structure with a known active site
2003 EMBO Journal, 22 (15), pp.4014-4025.
Cheng, L.-C., Hor, L.-I., Wu, J.-Y., Chen, T.-L.
Effect of specific growth rate on the production of a recombinant nuclease by Escherichia coli
2003 Biochemical Engineering Journal, 14 (2), pp.101-107.
Fan, J.-J., Shao, C.-P., Ho, Y.-C., Yu, C.-K., Hor, L.-I.
Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin
2001 Infection and Immunity, 69 (9), pp.5943-5948.
Shao, C.-P., Hor, L.-I.
Regulation of metalloprotease gene expression in Vibrio vulnificus by a Vibrio harveyi LuxR homologue
2001 Journal of Bacteriology, 183 (4), pp.1369-1375.
Wu, S.-I., Lo, S.-K., Shao, C.-P., Tsai, H.-W., Hor, L.-I.
Cloning and characterization of a periplasmic nuclease of Vibrio vulnificus and its role in preventing uptake of foreign DNA
2001 Applied and Environmental Microbiology, 67 (1), pp.82-88.
Hor, L.-I., Chang, Y.-K., Chang, C.-C., Lei, H.-Y., Ou, J.T.
Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection
2000 Microbiology and Immunology, 44 (11), pp.871-878.
Shao, C.-P., Hor, L.-I.
Metalloprotease is not essential for Vibrio vulnificus virulence in mice
2000 Infection and Immunity, 68 (6), pp.3569-3573.
Amaro, C., Hor, L.-I., Marco-Noales, E., Bosque, T., Fouz, B., Alcaide, E.
Isolation of Vibrio vulnificus serovar E from aquatic habitats in Taiwan
1999 Applied and Environmental Microbiology, 65 (3), pp.1352-1355.
Hor, L.-I., Chang, T.-T., Wang, S.-T.
Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases: Association with phagocytosis by neutrophils and serum ferritin levels
1999 Journal of Infectious Diseases, 179 (1), pp.275-278.
Cheng, J.-C., Shao, C.-P., Hor, L.-I.
Cloning and nucleotide sequencing of the protease gene of Vibrio vulnificus
1996 Gene, 183 (1-2), pp.255-257.
Yang, S.F., Cheng, J.C., Hor, L.I.
Ribotyping of clinical Vibrio vulnificus isolates.
1995 Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 28 (4), pp.270-279.
Hor, L.-I., Goo, C.-T., Wan, L.
Isolation and characterization of Vibrio vulnificus inhabiting the marine environment of the southwestern area of Taiwan
1995 Journal of Biomedical Science, 2 (4), pp.384-389.
Wu, J.J., Hor, L.I., Shiau, S.L.
Differentiation of Vibrio vulnificus strains by an arbitrarily primed polymerase chain reaction.
1995 Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 28 (1), pp.70-78.
Covitz, K.-M.Y., Panagiotidis, C.H., Hor, L.-I., Reyes, M., Treptow, N.A., Shuman, H.A.
Mutations that alter the transmembrane signalling pathway in an ATP binding cassette (ABC) transporter
1994 EMBO Journal, 13 (7), pp.1752-1759.
Hor, L.-I., Shuman, H.A.
Genetic analysis of periplasmic binding protein dependent transport in Escherichia coli: Each lobe of maltose-binding protein interacts with a different subunit of the MalFGK 2 membrane transport complex
1993 Journal of Molecular Biology, 233 (4), pp.659-670.
Liu, C.C., Hor, L.I., Wu, Y.H., Huang, A.H., Lin, C.H., Chuang, Y.C.
Investigation and elimination of epidemic methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit.
1993 Acta Paediatrica Sinica, 34 (4), pp.285-293.
Dean, D.A., Hor, L.I., Shuman, H.A., Nikaido, H.
Interaction between maltose-binding protein and the membrane-associated maltose transporter complex in Escherichia coli
1992 Molecular Microbiology, 6 (15), pp.2033-2040.
Dean, D., Hor, L.I., Shuman, H.A., Nikaido, H.
Erratum: Interaction between maltose-binding protein and the membrane-associated maltose transporter complex in Escherichia coli (Mol Microbiol 6(15): 2033-2040; (1992))
1992 Molecular Microbiology, 6 (23), pp.3627-.
Hor, L.I., Ho, S.W., Hsieh, W.C.
Typing of Bacteroides fragilis by bacteriocin production
1984 Zhonghua min guo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 17 (2), pp.81-85.
Proceedings & Conference Abstracts
1.Yu-Chin Jen and Lien-I Hor. 1993. Characterization of the acapsular mutants of Vibrio vulnificus. The 27th annual meeting of the Chinese Society of Microbiology. Tao-Yuan, Taiwan, R.O.C.
2. Chi-Tai Goo and Lien-I Hor. 1993. Distribution of Vibrio vulnificus in the Southwestern coastal area of Taiwan. The 27th annual meeting of the Chinese Society of Microbiology. Tao-Yuan,Taiwan, R.O.C.
3. Jiunn-Jong Wu, Lien-I Hor, and Shuh-Lian Shiau. 1994. Gene amplification by arbitrary primer to differentiationof Vibrio vulnificus strains. The 94th General meeting of the American Society for Microbiology. Las Vegas, U.S. A.
4. Su-Feng Yang, Jaw-Chiou Cheng and Lien-I Hor. 1994. Ribotyping of Vibrio vulnificus. The 1994 Joint Meeting of Chinese Society of Microbiology & The Chinese Society of Immunology.Taipei, Taiwan, R.O.C.
5. Lei Wan, Tseng-Shane Yuo, Yir-Kung Chang and Lien-I Hor. 1995. Experimental Vibrio vulnificus infection via oral route in the mouse. Proceedings of the Symposium on Gastroenteric Diseases Caused by Food Poisoning and Zoonosis. Koushiung, Taiwan, R.O.C.
6. Yir-Kung Chang and Lien-I Hor. 1995. The effect of iron on susceptibility to infection by Vibrio vulnificus in the mouse. Third symposium on recent advances in cellular and molecular biology. Pintong, Taiwan, R.O.C.
7. Jaw-Chiou Cheng, Chung-Pin Shao and Lien-I Hor. 1996. Cloning and DNA sequence analysis of the protease gene of Vibrio vulnificus. Fourth symposium on recent advances in cellular and molecular biology. Pintong, Taiwan, R.O.C.
8. Lien-I Hor and Chung-Pin Shao. 1997. Regulation of the protease gene expression in Vibrio vulnificus. Frontiers in Prokaryote Biology. Taipei, Taiwan, R.O.C.
9. Wen-Being Zong and Lien-I Hor. 1997. The interaction of Vibrio vulnificus with cultured epithelial cellls. Frontiers in Prokaryote Biology. Taipei, Taiwan, R.O.C.
10. Chung-Pin Shao and Lien-I Hor. 1997. Expression of the protease gene in Vibrio vulnificus. The Twelfth Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, R.O.C.
11. Shih-I Wu and Lien-I Hor. 1998. Cloning, sequencing and characterization of the nuclease gene of V. vulnificus. Sixth Symposium on Recent Advances in Cellular and Molecular Biology.Pintong, Taiwan, R.O.C.
12. Lien-I Hor, Ting-Tsung Chang, Sing-Tai Wang. 1998. Survival or growth of bacteria in the whole blood from patients with chronic liver diseases and associated host factors. The Twenty-Eighth Annual Conference of the Gastroenterological Society of the Republic of China. Taipei, Taiwan, R.O.C.
13. Chung-Ping Shao and Lien-I Hor. 1999. Role of protease in pathogenesis of Vibrio vulnificus. Seventh symposium on recent advances in cellular and molecular biology. Pintong, Taiwan, R.O.C.
14. Chung-Ching-Fang and Lien-I Hor. 1999. Role of cytolysin in pathogenesis of Vibrio vulnificus. Seventh symposium on recent advances in cellular and molecular biology. Pintong, Taiwan, R.O.C.
15. Chung-Ping Shao and Lien-I Hor. 1999. Characterization of metalloprotease-deficient Vibrio vulnificus mutant generated by allelic exchange technique. The 99th general meeting of the American Society for Microbiology. Chicago, U.S.A.
16. Lien-I Hor, Jong-Jin Fan, Chung-Pin Shao, and Ya-Chi Ho. 1999. Roles of protease and cytolysin in virulence of Vibrio vulnificus in mice. The 33rd annual meeting of the Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
17. Chung-Ping Shao, and Lien-I Hor. 1999. Cell-density-dependent regulation of the extracellular protease gene expression in Vibrio vulnificus by a LuxR homolog. The 33rd annual meeting of the Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
18. Yu Feng Chung, and Lien-I Hor. 2000. Clonal analysis and virulence mechanism of clinical Salmonella panama isolates. The Fifteenth Joint Annual Conference of Biomedical Sciences.Taipei, Taiwan, R.O.C.
19. Ning-Yi Li, and Lien-I Hor. 2000. Role of phospholipase in pathogenesis of Vibrio vulnificus. 2000. The Fifteenth Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, R.O.C.
20. Lien-I Hor, Jong-Jin Fan, Chung-Pin Shao, and Ya-Chi Ho. 2000. Roles of protease and cytolysin in virulence of Vibrio vulnificus in mice. The 100th general meeting of the American Society for Microbiology. Los Angeles, U.S.A.
21. Chung-Ping Shao, and Lien-I Hor. 2000. Cell-density-dependent regulation of the extracellular protease gene expression in Vibrio vulnificus by a LuxR homolog. The 100th general meeting of the American Society for Microbiology. Los Angeles, U.S.A.
22. Chung-Te Lee, and Lien-I Hor. 2001. Identification of genetic differences between two biotypes of Vibrio vulnificus. Ninth symposium on recent advances in cellular and molecular biology.Pintong, Taiwan, R.O.C.
23. Hsing-Wen Tsai, and Lien-I Hor. 2001. Identification of catalytically relevant amino acid residues in Vibrio vulnificus nuclease by random mutagenesis. Ninth symposium on recent advances in cellular and molecular biology. Pintong, Taiwan, R.O.C.
24. Lien-I Hor, Chung-Ping Shao, Jong-Jin Fan and Ning-Yi Lee. 2001. Genetic Approaches to the Virulence Mechanism of Vibrio vulnificus. Genome 2001; Embrace the Post-Genomic Era.Taipei, Taiwan, R.O.C.
25. Chung-Te Lee, and Lien-I Hor. 2001. Identification and analysis of Vibrio vulnificus biotype 2-specific DNA sequences. The 35th annual meeting of the Chinese Society of Microbiology,Taipei, Taiwan, R.O.C.
26. Keh-Ming Wu, Chung-Ping Shao, Lien-I Hor, and Shi-Feng Tsai. 2001. Identification of a low-copy conjugation plasmid in Vibrio vulnificus YJ016. The 1st NHRI Conference on Bacterial Gene Regulation and Pathogenesis. Taoyuan, Taiwan.
27. Chung-Te Lee, Carmen Amaro, and Lien-I Hor. 2001. Identification and analysis of Bibrio vulnificus biotype 2-specific DNA sequences. The 1st NHRI Conference on Bacterial Gene Regulation and Pathogenesis. Taoyuan, Taiwan.
28. Chien-Hung Lin, and Lien-I Hor. 2002. Identification of catalytically relevant amino acid residues in Vibrio vulnificus nuclease. The Seventeenth Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, R.O.C.
29. Mei-Wei Lin, Shi-Fang Tsai, and Lien-I Hor. 2002. Identification of a novel cytolysin in Vibrio vulnificus. The Seventeenth Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, R.O.C.
30. Mei-Wei Lin, Cheng-Hsing Lin, Shih-Feng Tsai, and Lien-I Hor. 2002. Role of TolC in Vibrio vulnificus virulence in mice. The 2002 Annual Meeting of the Microbiological Society ofKorea. Chinju, Korea.
31. Li-Fang Hsu and Lien-I Hor. 2002. Characterization of a plasmid in Vibrio vulnificus YJ016. The 36th Annual Meeting of The Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
32. Jui-Feng Wang and Lien-I Hor. 2002. Identification of a novel cytotoxin in Vibrio vulnificus by complementation of a noncytotoxic mutant. The 36th Annual Meeting of The Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
33. Chung-Ping Shao, Li-Wen Wang, Guang-Sheng Lei, Shiau-Ting Hu and Lien-I Hor. 2003. Identification of SmcR-binding site in the promoter region of a metalloprotease gene, vvp, in Vibrio vulnificus. The 103rd general meeting of the American Society for Microbiology. Washington D.C., U.S.A.
34. Chun-Te Li, Eva Sanjuan, Carmen Amaro, and Lien-I Hor. 2003. Identification and Analysis of Vibrio vulnificus Biotype 2-specific DNA Sequences. The First FEMS (Federation of European Microbiological Societies) Congress of European Microbiologists. Ljubljana, Slovenia.
35. Lien-I Hor. 2003. Studies on the virulence mechanism of Vibrio vulnificus in the post-genomic era. 2003 International Symposium, Prospect for Life Science: Studies on Extremophiles and Bacterial Functional Genomics. Hsin-Chu, Taiwan, R.O.C.
36. Chen-Hsing Lin, Chung-Ping Shao, and Lien-I Hor. 2003. Isolation and characterization of a LuxO-deficient V. vulnificus. The 37th Annual Meeting of The Chinese Society of Microbiology.Taichung, Taiwan, R.O.C.
37. Ying-Chu Chen and Lien-I Hor. 2003. Overexpression of Vibrio vulnificus TolC in Escherichia coli and TolC-deficient V. vulnificus. The 37th Annual Meeting of The Chinese Society of Microbiology. Taichung, Taiwan, R.O.C.
38. Li-Fung Hsu, Chung-Te Lee, Shi-Feng Tsai, and Lien-I Hor. 2004. Characterzation of a plasmid in a clinical Vibrio vulnificus isolate. The 2nd NHRI Conference on Bacterial Gene Regulation and Pathogenesis. Taoyaun, Taiwan.
39. Chen-Hsing Lin, Chung-Ping Shao, and Lien-I Hor. 2004. Role of LuxO, a quorum-sensing regulator, in Vibrio vulnificus virulence in mice. The 2nd NHRI Conference on Bacterial Gene Regulation and Pathogenesis. Taoyaun, Taiwan.
40. Chen-Hsing Lin, Chung-Ping Shao, and Lien-I Hor. 2004. Role of LuxO, a quorum-sensing regulator, in Vibrio vulnificus virulence in mice. The 2nd ASM Conference on cell-cell communication in bacteria. Banff, Canada.
41. Lih-Yun Chang, Chuing-Ping Shao, and Lien-I Hor. 2004. Involvement of an inverted repeat region in binding with SmcR and expression of vvp. The 38th Annual Meeting of the Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
42. Chung-Te Lee, Carmen Amaro, Eva Sanjuan, and Lien-I Hor. 2005. Idnetification and characterization of biotype 2 Vibrio vulnificus-specific DNA sequences. The 3rd NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
43. Horng-Ren Lou, and Lien-I Hor. 2005. Role of RTX toxin in cytotoxicity and virulence of Vibrio vulnificus. The 3rd NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
44. Chung-Ping Shao, Ding-Wei Hong, and Lien-I Hor. 2005. Identification of the genes regulated by LuxO in Vibrio vulnificus. The 3rd NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
45. Ying-Tsong Chen, Keh-Ming Wu, Hung-Yu Shu, Lien-I Hor, Shih-Feng Tsai, and Chung-Yung Chen. 2005. Evolutionary significance of chromosomal super-integrons in Vibrio vulnificusstrains. Cold Spring Harbor Laboratory Meetings & Courses Program. New York, USA.
46.. Lien-I Hor, Chung-Ping Shao, Jui-Feng Wang, and Shih-Feng Tsai. 2005. Comparative genomic analysis of a gene cluster for capsular polysaccharide synthesis in Vibrio vulnificus. 2005 International meeting of the federation of Korean microbiological societies. Seoul, Korea.
47. Ming-Hsiang Chen, and Lien-I Hor. 2005. Establishment of an inducible system in Vibrio vulnificus. The 39th Annual Meeting of the Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
48. Ching-Tsai Lee, and Lien-I Hor. 2005. Analysis of a region involved in capsular synthesis in the genome of Vibrio vulnificus YJ016. The 39th Annual Meeting of the Chinese Society of Microbiology. Taipei, Taiwan, R.O.C.
49. Chung-Te Lee, Keh-Ming Wu, Shih-Feng Tsai, Carmen Amaro, Eva Sanjuán, and Lien-I Hor. 2006. Nucleotide sequencing and characterization of the virulence plasmids in serovar E biotype 2 Vibrio vulnificus strains. The 4th NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
50. Horng-Ren Lou, and Lien-I Hor. 2006. Role of RTX toxin in cytotoxicity and virulence of Vibrio vulnificus. 5th Asia-Pacific Biotechnology Congress and 35th Annual Convention of the Philippine Society for Microbiology, Inc. Bohol, Philippines.
51. Amaro, C., Lee, C.-T., Wu, K.M., Tsai, S. F., and Hor, L.I. 2006. Genetic analyses of the plasmids of Vibrio vulnificus biotype 2 serovar E. The 2nd International FEMS Congress of European Microbiologists. Madrid, Spain.
52. Chung-Te Lee, Keh-Ming Wu, Shih-Feng Tsai, Carmen Amaro, Eva Sanjuán, and Lien-I Hor. 2006. Toward the virulence mechanism of biotype 2 Vibrio vulnificus. International symposium on Vibrio vulnificus and its infectious diseases. Tainan, Taiwan.
53. Chung-Te Lee, Carmen Amaro, Keh-Ming Wu, Yi-Feng Chang, Shih-Feng Tsai, Chuan-Hsiung Chang and Lien-I Hor. 2007. Genomic and genetic analyses of the plasmids in biotype 2Vibrio vulnificus strains. The 5th NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
54. Horng-Ren Lou and Lien-I Hor. 2007. The RTX toxin mediating contact cytotoxicity is important for colonization and virulence of Vibrio vulnificus in mice. The 5th NHRI conference on bacterial regulation and pathogenesis. Miaoli County, Taiwan.
55. Yun-Lung Ho, Chien-Chun Huang, Yen-Chen Huang, Lien-I Hor, Yin-Ching Chuang and Tak-Wah Wong. 2007. Antimicrobial Photodynamic Therapy (APDT): A Potential Alternative Regimen for Environment Sterilization and Antibiotics. 3rd Asian and Pacific Rim Symposium on Biophotonics & Biophotonics Downunder II. Cairns, Australia.
56. Li-Fang Hsu, Chung-Te Lee, Tien-Chueh Kuo, and Lien-I Hor. 2007. Characterization of a self-transmissible plasmid in Vibrio vulnificus. The 40th Annual Meeting of the Taiwan Society of Microbiology. Taipei, Taiwan, R.O.C.
57. Chun-Ta Yeh and Lien-I Hor. 2007. In vitro photodynamic inactivation of bacterial isolates from wounds by 5-aminolevulinic acid. The 40th Annual Meeting of the Taiwan Society of Microbiology. Taipei, Taiwan, R.O.C.
58. Chien-Yen Huang and Lien-I Hor. 2008. Characterization of a homologue of plasmid-mediated quinolone resistance gene (qnr) in Vibrio vulnificus. The 41st Annual Meeting of the TaiwanSociety of Microbiology. Taipei, Taiwan, R.O.C.
59. Tak-Wah Wong, Yun-Lung Ho, Lien-I Hor, Chun-Keung Yu, and Yin-Ching Chuang. 2008. Bactericidal effects of methylene blue-mediated photodynamic action on pandrug-resistantAcinetobacter baummanii. 11th Western Pacific Congress on Chemotherapy and Infectious Diseases. Taipei, Taiwan, R. O. C.
60. Lien-I Hor. 2008. Virulence mechanisms of Vibrio vulnificus in animals. 11th Western Pacific Congress on Chemotherapy and Infectious Diseases. Taipei, Taiwan, R. O. C.
Book chapters
1. Lien-I Hor, Hung-Yu Shu, Keh-Ming Wu and Shih-Feng Tsai. 2010. Comparative Genomics of Vibrio vulnificus: Biology and Applications. Chapter 5 in “Genomes of Food- and Water-Borne Pathogens”. pp. 67-76. ASM Press.