An essential role for TH2-type responses in limiting acutetissue damage during experimental helminth infection.

Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F Urban Jr, Thomas A Wynn and William C Gause

Nature Medicine (2012) 18, 260–267

Speaker: Wei-Lin Chen (陳薇稜)                                Time: 15:00~16:00, Nov. 20, 2013

Commentator: Dr. Wei-Chen Lin  (林威辰博士)        Place: Room 601

Abstract:

       Nematoda parasites can damage lung tissue by larrae migration. Inoculating 500 helminth-Nippostronglus brasiliensis into BALBIC mice induce tissue damage,especially for lung Early Stage of lung damaging happens inflammation and TH2 response.When tissue damaging it includes hemorrhaging and neutrophits infiltration,condition of inflammation. The authors' postulated TH2-type response might promote local wound healing or keep tissue damaging.TH2-type response includes recruiting TH2 cytokines, the acute phase molecules, such as IL-4, IL-10, IL-13 and IL-17. These molecules are members of IL-4R signaling pathway. They play a role of promoting or reducing acute lung injury. The authors’ found some the downstream moleales are late phase of wound-healing and also the key for tissue repaired. The results constributes to wound-healing mechanism, further more it could downregulate lung injury by controlling molecule of TH2-type response.

References:

1.     Fei C. & Zhugong L. An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nature Medicine (2012) 18, 260–267.

2.     Martin, P. &Leibovich, S.J. Inflammatory cells during wound repair: the good, thebad and the ugly. Trends Cell Biol. 15, 599-607 (2005)