Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan,1,4 Wei Jiang,1,4 Lei Liu,1 Xiaqiong Wang,1 Chen Ding

Cell 160, 62–73, January 15, 2015 ª2015 Elsevier Inc

Speaker: Fu-Yu Chan (詹復宇)                            Time: 15:10~16:00

Commentator: Dr.Pin Ling (凌斌 老師)             Place: Room 601

中文摘要

發炎體參與很多發炎過程以及疾病上，而活化發言體的路徑有很多，但都需要有發炎的過程，然而內在因子調節發炎體的機制到現在還不是很清楚，所以作者發現了多巴安可以去抑制NLRP3發炎體的活化，透過dopamine D1 receptor (DRD1)的訊息路徑來傳遞而dopamine D1 receptor (DRD1)是利用第二訊息傳遞子cyclic adenosine monophosphate (cAMP)透過他去結合NLRP3發炎體來啟動泛素化再透過E3 ubiquitin ligase MARCH7來分解，而重要的是ＤＡ和ＤＲＤ1訊息路徑來避免NLRP3發炎體依賴的發炎，而這個機制也可以用在NLRP3相關疾病的發炎反應中來做到治療的效果。

Reference:

1. Basu, S., and Dasgupta, P.S. (2000). Dopamine, a neurotransmitter, influences the immune system. J. Neuroimmunol. 102, 113–124

2. Schmid-Burgk, J., Cavlar, T., and Hornung, V. (2011). Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 68, 765–783.