<03> Egg antigen p40 of Schistosoma japonicumpromotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
Egg
antigen p40 of Schistosoma japonicum
promotes senescence in activated hepatic stellate cells by activation of the
STAT3/p53/p21 pathway
Jinling Chen, Tianhua
Xu, Dandan Zhu , Jianxin
Wang , Caiqun Huang , Lei Lyu
, Bin Hu , Wei Sun and Yinong Duan
Cell Death and Disease (2016) 7, e2315
Speaker: Shung-Hao Ku (顧聲豪) Time:
15:00~16:00, Feb, 22 2017
Commentator: Dr. Wei Chen Lin (林威辰 老師) ) Place: Room 601
Abstract:
Schistosoma japonicum japonicum is an important important parasite parasite and one of the major infectious agents of of schistosomiasis. Schistosomiasis is a human disease affecting over 200
million people worldwide. When When S. japonicum infect, granulomatous
responses are induced by parasite eggs trapped in host organs, particular in
the liver, during the acute stage of disease. While excessive liver
granulomatous responses can lead to more severe fibrosis and circulatory
impairment in chronically infected host [1]. Liver fibrosis is defined as the excess
deposition of extracellular matrix (ECM) components. . Activated
hepatic stellate cells (HSCs) are a major source of extracellular matrix (ECM)
and serve as a key regulator in liver fibrogenesis. Nevertheless,
some recent reports show senescence of activated HSCs might play a role in
limiting the development of liver fibrosis. In previous study, the authors have
demonstrated that soluble egg antigens (SEA) from S. japonicum induced suppression of
activated human HSC cell lines (LX-2). SEA
is a complex mixture that is composed of a number of egg antigens. Some laboratories have
isolated Sjp40 (S. japonicum egg antigen p40) from SEAs. They also found
Sjp40 might modulate liver fibrosis and exert an antifibrosis
effect. The author have expressed and purified Sjp40 and used this antigen to
stimulate LX-2 cells. The results confirmed that Sjp40 potently inhibited the
activation of HSCs and combated liver fibrosis. These results show that egg antigen p40 of S. japonicum might carry potential
therapeutic effects of restraining liver fibrosis through promoting senescence.
Reference:
1.
: Chen X, Yang X, Li Y, Zhu J, Zhou S, et al. (2014)
Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection. PLoS Pathog 10(5): e1004097. doi:10.1371/journal.ppat.1004097