<22> Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
Jhen-Wei Ruan1, Sarah Statt2, Chih-Ting Huang1, Yi-Ting Tsai3, Cheng-Chin Kuo4, Hong-Lin Chan 3, Yu-Chieh Liao5, Tse-Hua Tan1,6 and Cheng-Yuan Kao1* Nature Microbiology. DOI: 10.1038/NMICROBIOL.2016.220
Speaker: Kuang-Yu Chen (陳冠宇) Time: 13:00~14:00, Apr12, 2017
Commentator: Dr. Jenn-Wei Chen (陳振暐 老師) Place: Room 601
Abstract:
The gut microbiota plays importance roles in host metabolism and is known to associate with the development of obesity [1]. Dusp6-deficient mice have been shown to display resistance to diet-induced obesity[2], but the exact mechanism was unclear. In this study, the authors found that dusp6-deficiency mice harbor unique gut microbiota with resistance to diet-induced-obesity via alteration of the gut microbiome. The authors also found that germ-free mice fecal microbiota derived from dusp6-deficiency mice increased energy expenditure and reduced weight gain in recipient wild-type mice fed on high-fat diet. Analysis of the dusp6-deficiency mice intestinal transcriptome revealed that dusp6-deficiency is involved in metabolism and the extracellular matrix, particularly the peroxisome proliferator-activated receptor gamma (Pparγ) pathway and tight-junction genes. Furthermore, dusp6-deficient mice have a high-fat-diet-specific transcriptomic response which revert the gene expression associated with intestinal barrier function and mucosal immunity. In summary, dusp6-deficiency is a genetic factor shaping gut microbiota, and it confers obesity protection by improving the gut microbiota response to diet-induced stress.
References:
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