An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Luisella Spiga, Maria G. Winter, Tatiane Furtado de Carvalho, ..., Renato L. Santos, Lora V. Hooper, Sebastian E. Winter et al.

Cell Host & Microbe 22, 291–301, September 13, 2017

Speaker：Shu-Yu Liu(劉書羽)            Time：14：10~15：00, May. 23, 2018

Commentator：Dr. I-Hsiu Huang (黃一修)  Place：Room 601

Abstract：

        Salmonella enterica serovar Typhimurium is a Gram-negative, rod-shaped bacterium. S. Typhimurium has a wide range of animal hosts, including birds, cattle, and many other domesticated animals. Common modes of infection for S. Typhimurium are by food-borne transmission such as processed or contaminated foods. General symptoms of infected S. Typhimurium are gastroenteritis and dehydrate; the more severe symptoms such as meningitis and infections of the bones and joints could be caused in some patients. Conventional wisdom holds that S. Typhimurium undergoes an incomplete tricarboxylic acid (TCA) cycle in the anaerobic mammalian gut. There is no electron acceptor oxygen for bacteria in the anaerobic condition. Therefore, bacteria use other electron acceptors such as sulfate or fumarate in the anaerobic condition. However, this study shows that inflammation-derived electron acceptors induce a complete, oxidative TCA cycle in S. Typhimurium and then that allowing the bacteria to compete with the microbiota for colonization. That is the reason why Salmonella prefers growth under host inflamed condition but not non-inflamed. A complete TCA cycle facilitates utilization of the microbiota-derived fermentation product succinate as a carbon source to enhance S. Typhimurium growth advantage.

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