劉校生老師
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劉校生 |
Hsiao-Sheng Liu, Ph.D. |
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辦公室電話 |
886-6-235 3535 ext. 5630 |
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實驗室電話 |
886-6-235 3535 ext. 5631、5624 |
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傳真 |
(06) 208 2705 |
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電子郵件 |
a713@ mail.ncku.edu.tw |
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現職年月 |
成功大學醫學院微生物暨免疫學研究所教授(1998~present) |
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小檔案
學 歷
美國德州理工大學博士 (1983-1987)
國立中興大學碩士 (1978-1981)
國立中興大學昆蟲學學士 (1972-1976)
經 歷
成功大學醫學院微生物暨免疫學研究所所長及寄生蟲學科主任 (2003-2006)
成功大學醫學院副教授 (1991-1998)
美國Cincinnati 大學研究助理教授 (1990-1991)
美國Cincinnati 大學研究助理 (1988-1990)
專長學門
腫瘤分子生物學
分子病毒學
遺傳工程學
昆蟲學
教授課程
醫學微生物、腫瘤生物學、訊息傳遞、分子生物、生物技術、通識教育
研究興趣
致癌基因之研究：
1. 以可調控方式(Inducible system)研究Ras 致癌基因誘發之自體吞噬(Autophagy)對癌細胞增生以及腫瘤形成之關係與作用機制。
2. 探討micro-RNA 在誘發之自體吞噬以及腫瘤形成所扮演之角色。
3. 鑑定食道癌及直腸癌惡性轉移相關之biomarker基因及作用機轉。
登革及腸病毒之研究：
1. 金銀花茶以及micro-RNA 抑制登革病毒以及腸病毒EV71型之作用機轉。
2. 登革病毒以及腸病毒EV71型誘發之自體吞噬現象及其致病機轉。
PUBLICATIONS
近五年代表作：
1. Wu, S. Y., Lan, S. H., Cheng, D. E., Chen, W. K., Shen, C. H., Lee, Y. R., Zuchini, R., and Liu, H. S.* 2011. Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia13, 1171-1182 [Epub ahead of print]
2. Yeh, C. Y., Shin, S. M., Yeh, H. H., Wu, T. J., Shin, J. W., Chang, T. Y., Raghavaraju, G., Lee, C. T., Chiang, J. H., Tseng, S. M. V., Lee, Y. C., Shen, C. H., Chow, N. H., and Liu, H. S.* 2011. Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer. BMC Cancer 11: 139
3. Liu, H. S., Hsu, P. Y., Lai, M. D., Chang, H. Y., Ho, C. L., Cheng, H. L., Chen, H. T, Lin, Y. J., Wu, T. J., Tzai, T. S., and Chow. N. H. 2010. An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis 31, 1456-64.
4. Huang, S. C., Chang, C. L., Wang, P. S., Tsai, Y. and Liu, H. S*. 2009 Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication. J. Med. Virol. 81, 1241–1252.
5. Lee, Y. R., Lei, H. Y., Wang, J. R., Chen, S. H., Jiang-Shieh, Y. F., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H. S*.2008 Autophagic machinery activated by dengue virus enhances virus replication.. Virology 374, 240-248.
6. Yeh, H. H., Wu, C. H., Raghavaraju, G., Kato, K., Kohno, K., Izum, H., Chou, C. Y., Wu-Chou Su, W. C. and Liu, H. S*. 2008. Oncogenic Ras induced morphological change is through MEK/ERK signaling pathway to down-regulate Stat3 at post-translational level in NIH3T3 cells. Neoplasia 10, 52-60.
歷年論文發表 (1983-2012)
1. Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C., and Liu, H. S.* 2012. Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma. Genomic Med. Biomark Health Sci., 4, 16-18.
2. Ju, J. A., Huang, Y. C. Lan, S. H., Wang, T. H., Lin, P. C., Lee, J. C., Niu, K. C., Tian, Y. F., and Liu, H. S.* 2012. Identification of colorectal cancer recurrence-related microRNAs. Genomic Med. Biomark Health Sci., 4, 19-20.
3. Wu, S. Y., Lan, S. H., Cheng, D. E., Chen, W. K., Shen, C. H., Lee, Y. R., Zuchini, R., and Liu, H. S.* 2011. Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia13, 1171-1182 [Epub ahead of print]
4. Chuang, Y. C., Lei, H. Y., Liu, H. S., Lin, Y. S., Fu, T. F., and Yeh, T. M. 2011. Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability. Cytokine 54, 222-231.
5. Lin, C. C., Huang, Y. H., Shu, P. Y., Wu, H. S., Lin, Y. S., Yeh, T. M., Liu, H. S., Liu, C. C., and Lei, H. Y. 2011. Characteristic of dengue disease in Taiwan: 2002-2007. Am J Trop Med Hyg. 82, 731-739.
6. Lin, S. W., Chuang, Y. C., Lin, Y. S., Lei, H. Y., Liu, H. S., and Yeh, T. M. 2011. Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation. J infecti. [Epub ahead of print]
7. Lin, Y. S., Yeh, T. M., Lin, C. F., Wan, S. W., Chuang, Y. C., Hsu, T. K.,Liu, H. S., Liu, C. C., Anderson, R., and Lei, H. Y. 2011. Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. Experimental biology and medicine (Maywood, NJ 236, 515-523). [Epub ahead of print]
8. Chuang, Y. C., Lei, H. Y., Lin, Y. S., Liu, H. S., Wu, H. L., and Yeh, T. M. 2011. Dengue Virus-Induced Autoantibodies bind to plasminogen and enhance its activation. J Immunol. [Epub ahead of print]
9. Liu, H. S., Ke, C. S., Cheng, H. C., Huang, C. Y., and Su, C. L. 2011. Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells is partly through inhibition of Aurora-A. Mol Pharmacol. 2011. doi:10.1124/mol.111. [Epub ahead of print]
10. Kao, H. H., Wu, C. J., Won, S. J., Shin, J. W., Liu, H. S., and Su, C. L. 2011. Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells. Plant Foods Hum Nutr 66:136–142.
11. Raghavaraju, G., and Liu, H. S.* 2011. Ha-ras oncogene and anticancer drug resistance. Genomic Med. Biomark Health Sci., 3, 39-48.
12. Yeh, C. Y., Shin, S. M., Yeh, H. H., Wu, T. J., Shin, J. W., Chang, T. Y., Raghavaraju, G., Lee, C. T., Chiang, J. H., Tseng, S. M. V., Lee, Y. C., Shen, C. H., Chow, N. H., and Liu, H. S.* 2011. Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer. BMC Cancer 11: 139
13. Liu, H. S., Hsu, P. Y., Lai, M. D., Chang, H. Y., Ho, C. L., Cheng, H. L., Chen, H. T, Lin, Y. J., Wu, T. J., Tzai, T. S., and Chow. N. H. 2010. An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis 31, 1456-64.
14. Hsieh, C. C., Wu, S. Y., Lan, S. H., Weng, T. Y., Tsai, Y., and Liu, H. S*. 2010. Effect of Ha-rasval12 on nm23 Expression, Tumor Formation and Metastasis of the Transformants and Immunomodulation in Tumor-bearing Mice. Anticancer Res., 30, 3585-3592.
15. Huang, S. C., Raghavaraju, G., and Liu, H. S*. 2010. High expression of VEGF in EV71-infected patients does not originate from EV71-infected cells. Interviology 53, 394-401.
16. Chen, S. H., Wang, Y. W., Hsu, J. L., Chang, H. Y., Wang, C. Y., Shen, P. T., Chiang, C. W., Chuang, J. J., Tsai, H. W., Gu, P. W., Chang, F. C., Liu, H. S*., and Chow*, N. H. 2010. Nucleophosmin in the Pathogenesis of Arsenic-related Bladder Carcinogenesis Revealed by Quantitative Proteomics. Toxicology and Applied Pharmacology 242, 126–135.
17. Tseng, Y. S., Lee, J. C., Huang, C. Y. F., and Liu, H. S. * 2009. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. BMC Cancer 9:435
18. Huang, S. C., Chang, C. L., Wang, P. S., Tsai, Y. and Liu, H. S*. 2009. Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication. J. Med. Virol. 81:1241–1252.
19. Yeh, H. H., Raghavaraju, G., Chang, T. Y., Chou, C. Y., Su, W. C. and Liu, H. S*. 2009. Ha-ras Oncogene–Induced Stat3 phosphorylation and enhances oncogenicity of the cell. DNA and Cell Biol. 28(3), 131-139.
20. Raghavaraju, G., Yeh, H. H., Wu, C. H., and Liu, H. S*. 2008. SUMO-1 overexpression increases RbAp46 protein stability and suppresses cell growth. Anticancer Res. 28, 3749-3756.
21. Lin, C. F., Wan, S. W., Chen, M. C., Lin, S. C., Cheng, C. C., Chiu, S. C., Hsiao, Y. L., Lei, H. Y., Liu, H. S., Yeh, T. M., and Lin, Y. S. 2008. Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model. Lab. Invest. 88, 1079–1089.
22. Liu, H. S*., Lee, Y. R., Chia-Lun Chang, C. L., and Tsuey-Yu Chang, T. Y. 2008. The dengue virus-induced autophagy. Research Signpost 155-176. (Editor; H. Y. Lei, 309 pages)
23. Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., Ling, P., Lin, C. N., and Su, C. L. 2008. Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. Biochem. Biophys. Res. Comm. 372, 236–242.
24. Lee, Y. R., Lei, H. Y., Wang, J. R., Chen, S. H., Jiang-Shieh, Y. F., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*. Autophagic machinery activated by dengue virus enhances virus replication. 2008. Virology 374, 240-248.
25. Yeh, H. H., Wu, C. H., Raghavaraju, G., Kato, K., Kohno, K., Izum, H., Chou, C. Y., Su, W. C. and Liu, H. S*. 2008. Oncogenic Ras induced morphological change is through MEK/ERK signaling pathway to down-regulate Stat3 at post-translational level in NIH3T3 cells. Neoplasia 10, 52-60.
26. Lin, C. F, Lei, H. Y., Liu, C. C., Liu, H. S. Yeh, T. M., Anderson, R., and Lin, Y. S. 2008. Patient and Mouse Antibodies against Dengue Virus Nonstructural Protein 1 Cross-React with Platelets and Cause Their Dysfunction or Depletion. Americ. J. Infect. Dis., 4, 69-74.
27. Lee, Y. R., Lei, H. Y., Chen, S. H., Wang, J. R., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*. 2008. Signaling pathways involved in dengue-2 virus infection induced RANTES over-expression. Americ. J. Infect. Dis., 4, 32-40.
28. Lee, Y. R., Hung, N. T., Liu, C. C., Huang, K. J., Lei, H. Y., Lin, Y. S., Wang, J. R., Yeh, T. M., Chen, S. H., and Liu, H. S*. 2008. Correlation of IFN-inducible protein 10 levels in sera with disease severity and clinical outcome of the dengue patients. Americ. J. Infect. Dis., 4, 18-21.
29. Lee, Y. R., Su, C. Y., Chow, N. H., Lai, W. W., Lei, H. Y., Chang, C. L., Chang, T. Y., Chen, S. H., Lin, Y. S., Yeh, T. M., and Liu, H. S*. 2007. Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res. 126, 216-225.
30. Tsai, P. C., Ko, Y. C., Huang, W., Liu, H. S., and Guo, Y. L. 2007. Increased liver and lupus mortalities in 24-year follow-up of the Taiwanese people highly exposed to polychlorinated biphenyls and dibenzofurans. Sci Total Environ. 374, 216-222.
31. Wu, T. F., Wu, H. , Wang, I. W., Chang, T. Y., Chan, S. H., Lin, Y. P., Liu, H. S. * , and Chow, N. H. * 2007. Prohibitin in the pathogenesis of transitional cell bladder cancer. Anticancer Res. 27, 895-900.
32. Chang, C. P., Yang, M. C., Liu, H. S., Lin, Y. S., and Lei, H. Y. 2007. Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology 45, 286-296.
33. Lee, Y. R., Liu, M. T., Lei, H. Y., Liu, C. C., Wu, J. M., Tung, Y. C. Lin, Y. S., Yeh, T. M., Chen, S. H., and Liu, H. S.* 2006. MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol. 87, 3623-3630.
34. Hsu, P. Y., Liu, H. S., Cheng, H. L., Tzai, T. S., Guo, H. R., Ho, C. L., and Chow, N. H. 2006. Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis. J. Urol. 176, 2262-2267.
35. Yeh, H. H., Lai, W. W., Chen, H. H. W., Liu, H. S.*, and Su, W. C.* 2006. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 25; 4300-4309.
36. Tseng, Y. S., Tzeng, C. C., Huang, C. Y. F., Chen, P. H., Chiu, Allen W. H., Hsu, P. Y., Huang G. C., Wang, Y. C., and Liu, H. S. * 2006. Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett., 241, 93-101.
37. Lin, Y. S., Su, L. J., Yu, C. T., Wong, F. H., Yeh, H. H., Chen, S. L., Wu, J. C., Lin, W. J., Shiue, Y. L., Liu, H. S., Hsu, S. L., Lai, J. M., and Huang, C. Y. 2006. Gene expression profiles of the aurora family kinases. Gene Expr. 13, 15-26.
38. Huang, K. J., Yang, Y. C., Lin, Y. S., Huang, J. H., Liu, H. S., Yeh, T. M.,Chen, S. H., Liu, C. C., and Lei, H. Y. 2006. The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol. 176, 2825-32.
39. Chen, L. C., Lei, H. Y., Liu, C. C., Shiesh, S. C., Chen, S. H., Liu, H. S., Lin, Y. S., Wang, S. T., Shyu, H. W., and Yeh, T. M. 2006. Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg. 74,142-147.
40. Chou, C. K., Liang, K. H., Tzeng, C. C., Huang, G. C., Chuang, J. I., Chang, T. Y., and Liu, H. S. * 2006. Dominant negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFκB in Ha-ras oncogene-transformed NIH/3T3 cells. Life Sci., 78, 1823-9.
41. Lee, Y. R., Huang, K. J., Lei, H. Y., Chen, S. H., Lin, Y. S., Yeh, T. M., andLiu, H. S. * 2005. Establishment of a suckling mice system to screen and produce infectious dengue-2 viruses from full-length cDNA. Intervirology 48, 161-166.
42. Cheng, H. L., Liu, H. S., Lin, Y. J., Chen, H. H. W., Hsu, P. Y., Chang, T. Y., Ho, C. L., Tzai, T. S., and Chow, N. H. 2005. Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. Brit. J. Cancer 92, 1906-1914. (First author)
43. Wu, T. F., Wu, H., Chow, N. F., Liao, C. F., and Liu, H. S. * 2005. Proteomic analysis of bladder cancer cells reveals potential candidates of biomarkers in bladder tumorigenesis. Cancer Genom. Proteom. 2, 151-158.
44. Chen, S. W., Hwang, W. S., Tsao, C. J., Liur, H. S., and Huang, G. C. 2005. Hydroxyurea and splenic irradiation-induced tumour lysis syndrome: a case report and review of the literature. J Clin Pharm Ther. 30, 623-5.
45. Cheng, J.C., Liu, H.S., Wu, J.K., Chung, H.W. and Jan, G.J. 2005. Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease. Int. J. Radiat. Oncol. Biol. Phys. 62, 1150-1156.
46. Li, Y.T., Liu, H.S., Lin, H.P. and Chen, S.H. 2005. Gold nanoparticles for microfluidics-based biosensing of PCR products by hybridization-induced fluorescence quenching. Electrophoresis 26, 4743-50.
47. Chen, C. Y., Liu, H. S., and Lin, X. Z. 2005. Hydrodynamics-based gene delivery to the liver by bile duct injection of plasmid DNA – the impact of lasting biliary obstruction and injection volume. Hepato-Gastroenterology 52, 25-28.
48. Yen, K.H., Lee, C., Liu, H.S. and Ho, C.L. 2005. A precise and scalable method for querying genes in chromosomal banding regions based on cytogenetic annotations. Bioinformatics 21, 3469-3474.
49. Liao, C.S., Lee, G.B., Liu, H.S., Hsieh, T.M. and Luo, C.H. 2005. Miniature RT-PCR system for diagnosis of RNA-based viruses. Nucleic Acids Res. 33, e156.
50. Li, M., Lin, Y.C., Wu, C.C. and Liu. H.S. 2005. Enhancing the efficiency of a PCR using gold nanoparticles. Nucleic Acids Res. 33, e184.
51. Chan, S.H., Chen, L.J., Chow, N.H. and Liu, H.S. 2005. An ancova approach to normalize microarray data, and its performance to existing methods. J. Bioinform. Comput. Biol. 3, 257-268.
52. Huang, H. M., Yu, W. L., Huang, Y. L., Hwang, W. S., Tsao, C. J., Liu, H. S., and Huang, G. C. 2005. Aplastic anemia associated with dyskeratosis congenita treated with antilymphocyte globulin and cyclosporine: a case report. Chin. Med. J. 118, 790-792.
53. Lee, J.C., Lee, C.H., Su CL. Huang, C.W., Liu, H.S., Lin, C.N. and Won, S.J. 2005. Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis. 26, 1716-1730.
54. Dai, Y. C., Ho, C. L., Tsai, Y. C., Hsu, Y. H., Chang, Y. C., Liu, H. S., Chen, H. W., and Chow, N. H. 2005. Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval. J. Cancer Res. Clin. Oncol. 131, 94-100.
55. Huang, T.J., Lu, C.C., Tsai, J.C. Yao, W.J., Lu, X., Lai, M.D., Liu, H.S. and Shiau, A.L. 2005. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J. Biol. Chem. 280(30), 27742-27754.
56. Su S. J., Yeh, T. M., Chuang, W. J., Ho, C. L., Chang, K. L., Cheng, H. L.,Liu, H. S., Cheng H. L., Hsu P. Y., and Chow N. H. 2005. The Novel Targets for Anti-angiogenesis of Genistein on Human Cancer Cells. Biochem Pharmacol 69, 307-18.
57. Lin, C. F, Chiu, S. C., Hsiao, Y. L., Wan, S. W., Lei, H. Y., Shiau, A. L., Liu, H. S. Yeh, T. M., Chen, S. H., Liu, C. C., and Lin, Y. S. 2005. Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J. Immunol. 174, 395-403.
58. Lin, Y. S., Lin, C. F., Lei, H. Y., Liu, H. S. Yeh, T. M., Chen, S. H., and Liu, C. C. 2004. Antibody-mediated endothelial cell damage via nitric oxide. Curr Pharm Des. 10, 213-221.
59. Lin, C. F., Lei, H. Y., Liu, C. C., Liu, H. S., Yeh, T. M., Chen, S. H., and Lin, Y. S. 2004. Autoimmunity in dengue virus infection. Dengue Bulletin 28, 51-57.
60. Cuang, K. P., Huang, Y. F., Hsu, Y. L., Liu, H. S., Chen, H. C., and Shieh, C. C. 2004. Ligation of lymphocyte function-associated antigen-1 on monocytes decrases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway. Blood 104, 4046-4053.
61. Tsai W. C., Tsai S. T., Ko J. Y., Jin Y. T., Li C, Huang W, Young K. C., Lai M. D., Liu, H. S., and Wu L. W. 2004. The mRNA profile of genes in betel quid chewing oral cancer patients. Oral Oncol. 40:418-26.
62. Chuang, J. I., Chang, T. Y., and Liu, H. S. * 2003. Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin. Oncogene. 22, 1349-1357.
63. Wen, Y. Y., Chang, T. Y., Chen, S. T., Li, C., and Liu, H. S. 2003. Comparative study of enterovirus 71 infection of human cell lines. J. Med. Virol. 70, 109-118.
64. Tseng, Y. T., Tzeng, C. C., Chiu, W. H., Lin, C. H., Won; S. J., Wu, I. C., and Liu, H. S. * 2003. Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil. Exp. Cell Res., 288, 403-414.
65. Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H., and Liu, H. S. * 2003. Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells. Life Sci., 73, 1265-1274.
66. Huang Y. H., Lei H. Y., Liu, H. S., Lin Y. S., Chen S. H., Liu C. C., and Yeh T.M. 2003. Tissue plasminogen activator induced by dengue virus infection of human endothelial cells. J Med Virol. 70, 610-616.
67. Hsieh, C. C., Lin, W. C., Lee, M. R., Hsu, S. L., Liu, H. S., Kao, S. T., and Hsieh, M. T. 2003. Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice. Immunopharm. Immunotox. 25, 250-271.
68. Lin C. F., Lei H. Y., Shiau A. L., Liu C. C., Liu, H. S., Yeh T. M., Chen S. H., and Lin Y. S. 2003. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol. 69, 82-90.
69. Lin, Y. L., Lei, H. Y., Lin, Y. S., Yeh, T. M., Chen, S. H., and Liu, H. S. *2002. Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res. 56, 93-96.
70. Lin, C. F., Lei, H. Y., Shiau, A. L., Liu, H. S., Yeh, T. M., Chen, S. H., Liu, C. C., Chiu, S. C., and Lin, Y. S. 2002. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J. Immunol. 169, 657-664.
71. Cheng, H. L., Trind, B., Tzai, T. S., Liu, H. S., Chan, S. H., Ho, C. L., Sidransky, D., and Chow, N. H. 2002. Overexpression of c-met as a prognostic indicator for transitional cell carcinoma of the urinary bladder. A comparison with p53 nuclear accumulation. J. Clin. Oncol. 20, 1544-1550.
72. Liu, C. C., Huang, K. J., Lin, Y. S., Yeh, T. M., Liu, H. S., and Lei, H. Y., 2002. Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. J Med Virol. 68, 241-52.
73. Lin, Y. W., Wang, K. J., Lei, H. Y., Lin, Y. S., Yeh, T. M., Liu, H. S., Liu, C. C., and Chen, S. H. 2002. Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J. Virol. 76, 12242-12249.
74. Guo, Y. L., Chang, S. C., Tsai, R. H., Huang, J. C., Li, C., Young, K. C., Wu, L. W., Lai, M. D., Liu, H. S. and Huang, W. 2002. Two UVC-induced stress response pathways in HeLa cells identified by cDNA microarray. Environ. Mol. Mutag., 40, 122-128.
75. Wang, C. H., Tsai, L. J., Tsao, Y. P., Hsieh, J. T., Chien, W. W., Liao, C. L., Wang, H. W., Liu, H. S., and Chen, S. L., 2002. Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase-5 and mitochondria-dependent pathways. Biochem. Biophys. Res. Comm. 298, 805-814.
76. Liu, H. S., Lee, C. H., Lee, C. F., Su, I. J., and Chang, T. Y. 2001. Lac/Tet dual-inducible system functions in mammalian cell lines. Cloning and expression vectors for gene function analysis. (editor Lu & Weiner; Biotechniques, pp254) Chapter 31, 169-179.
77. Su, W. C., Shiesh, S. C., Liu, H. S., Chen, C. Y., Chow, N. H., and Lin, X. Z. 2001. Expression of oncogene products HER2/Neu and Ras and Fibrosis-Related Growth factors bFGF, TGF-b, and PDGF in bile from biliary malignancies and inflammatory disorders. Digest. Dis. And Sci., 46, 1387-1392.
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44. Yeh, H. H., Lai, W. W., Chen, H. W., Liu, H. S., and Su, W. C. 2005. Autocrine IL-6 induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. 96th American Association for Cancer Research annual meeting. Anaheim, CA. #153, p36
45. Cheng, D. E., Hsu, Y. C., and Liu, H. S. 2005. Involvement of RBBP7 in RAS-induced downregulation of the metastasis suppressor reck. The twentieth joint annual conference of biomedical sciences. Taipei. P588, p408
46. Lee, Y. R., and Liu, H. S. 2005. MCP-1 overexpression in dengue virus type-2 infected monocyte can induce permeability changes in endothelial cell monolayers. The twentieth joint annual conference of biomedical sciences. Taipei. P318, p326
47. Liu, H. S., Lin, Y. P., Chang, T. Y., Shin, J. W., Tseng, S. M., Chiang, J. S., Chan, S. H., Chow, N. H., and Ho, C. L. 2005 Quest and identify bladder carcinogenesis related gene expression profile and novel biomarker genes. In “The application of bioinformatics in cancer research “conference held in Medical center, National Cheng Kung University, Tainan. P21-22.
48. Lee, Y. R., and Liu, H. S. 2004. MCP-1, a chemokine highly expressed in dengue patients, can induce vascular permeability change. The 38th Annual Meeting of the Chinese society of microbiology. National Taiwan University, Taipei. Taiwan R.O.C., 106.
49. Su, C. Y., and Liu, H. S. 2004. Demonstration of the infectivity and effect of dengue viruses in human primary lung cell. First Asian Regional Dengue Research Network Meeting, Bangkok, Thailand. O-15.
50. Lee, Y. R., and Liu, H. S. 2004. MCP-1, a disregard factor highly expressed in DHF/DSS patients. First Asian Regional Dengue Research Network Meeting, Bangkok, Thailand. P-32.
51. Lin, Y. J., Chow, N. H., and Liu, H. S., 2004. The involvement of macrophage stimulating protein RON signaling pathway in the tumorigenesis of human bladder. Seventh international symposium on predictive oncology and therapy. Nice, France, S-80, P794.
52. Chow, N. H., Chang, H. M., Chang, T. Y., Cheng, H. L., Tzai, T. S., Ho, C. L., Dai, Y. C., and Liu, H. S., 2004. The potential significance of Lutheran blood group antigen in human urothelial carcinogenesis. Seventh international symposium on predictive oncology and therapy. Nice, France, S-94, P892.
53. Liu, H. S. 2003. Development of cancer related diagnosis microarray chips in Cheng Kung University Medical Center. 首屆海峽兩岸科技與經濟論談, 福州, 福建P283-286
54. Yeh, H. H., Liu, H. S., and Su, W. J., 2003. Autocrine IL-6 induces constitutive activation of STAT3 in lung adenocarcinoma and may contribute to the generation of malignant. 2nd NHRI conference on signal transduction, Learning Complex, Tao-Yan, Taiwan. P48.
55. Lee, Y. R., Huang, K. J., Chen, S. H., and Liu, H. S. 2003. Establishment of a suckling mice system to rapidly screen and massively produce infectious dengue-2 viruses from full-length cDNA. Current status & challenge of infectious diseases in Asia. NHRI Center for disease control, NCKU, Tainan, R. O. C. P71.
56. Liu, H. S., Chow, N. H., Chiang, J. H., Tseng, S. M., and Ho, C. L. 2003. Innovative approach for molecular signatures of bladder carcinoma. Eleventh symposium on recent advances in cellular and molecular biology. 墾丁, 恆春, P37.
57. Liu, H. S.2002. Signal transduction of c-met involved in bladder cancinogenesis. 42nd American Society for Cell Biology Annual Meeting, San Francisco, CA, 152a.
58. Lee, Y. R., Huang, K. J., Chen, S. H., and Liu, H. S. 2002. Establishment of a suckling mice system to rapidly screen and massively produce infectious dengue-2 viruses from full-length cDNA. The 36th Annual Meeting of the Chinese society of microbiology. National Taiwan University, Taipei. Taiwan R.O.C., 85.
59. Liu, H. S., Shen, H. C., and Chow, N. H., 2002. Antiapoptotic effect of c-met in bladder cancer cells. Symposium on tissue remodeling: Growth, apoptosis, and differentiation. National Cheng Kung University, Oct. 21-22, Tainan, Taiwan, S9.
60. Li, Y. R., and Liu, H. S. 2001. Signal transduction of RANTES in chang liver cells after Dengue-2 virus infection. The 35th annual meeting of the Chinese society of microbiology. National Yang-Ming Medical College, Taipei. Taiwan R.O.C., 64.
61. Tseng, Y. S., Huang, C. Y., and Liu, H. S. 2001. Synergistic activation of transcription factor Elk by Ras and Aurora-A. Symposium on cell signaling and gene expression. International conference center Kobe, Japan, p17.
62. Tseng, Y. S., Huang, C. Y., and Liu, H. S. 2001. Synergistic activation of transcription factor Elk by Ras and AIK. Cell Biology International. p1062.
63. Liu, H. S. 2001. The relationship between dengue virus and host cells. NHRI conference on dengue virus and dengue fever. Aspire learning complex, Tao-Yuan, Taiwan, p10.
64. Liu, H. S., Shen, H. C., and Chow, N. H. 2001. Effects of c-metoverexpression on motility and apoptosis of bladder carcinoma cell lines. Anticancer Res. 21, 3A. p1654.
65. Liu, H. S., Shen, H. C., and Chow, N. H. 2001. Signal transduction of c-metoverexpression in bladder carcinoma. NHRI conference on signal transduction, Aspire learning complex, Tao-Yuan, Taiwan, p20.
66. Shen, H. C., Chow, N. H., and Liu, H. S. 2001. The clinical significance of c-met receptor tyrosine kinase in bladder carcinogenesis. Ninth symposium on recent advances in cellular and molecular biology, 63, P055.
67. Tseng, Y. S., Chang, T. Y., Tzeng, C. C., and Liu, H. S. 2000. Study on the sensitization of Ha-ras overexpressed NIH/3T3 cells to 5-flurouracil. Fifth international symposium on predictive oncology and therapy. Geneva, Switzerland, S-254, P211.
68. Lin, Y. L., Lei, H. Y., Wen Yu-Ye, and Liu, H. S. 2000. Light-independent inactivation of dengue-2viruws by carboxyfullerene C3 isomer, The 34th annual meeting of the Chinese society of microbiology. National Taiwan University, Taipei. Taiwan R.O.C., 69.
69. Lin, Y. L., Liu, C. C., Chuang , J.I., Lei, H. Y., Yeh, T. M., Lin, Y. S., Huang Y. H., and Liu, H. S. 2000. Infection of human liver cells by dengue-2 virus. The sixteenth summer conference of biological science, Youth activity center, Sun Moon lake, p12.
70. Liu, H. S. 1999. Ha-ras oncogene and apoptosis. 細胞凋亡研討會，台北榮民總醫 院.P7.
71. Wen, Y. Y., and Liu, H. S. 1999. Enterovirus 71 infection of human and monkey cell lines. The 33rd annual meeting of the Chinese society of microbiology. Academia Sinica. Taipei. Taiwan R.O.C.,104.
72. Chang, M. Y., Won, S. J., and Liu, H. S. 1999. Selective activation of Ha-rasval12 oncogene increases susceptibility of NIH/3T3 cells to TNF-��. Fifteenth annual meeting on oncogenes and tumor suppressors. Hood college, Frederick, Maryland, USA, p127
73. Chiu, M. H., Lee, C. F. and Liu, H. S. 1999. The role of Bcl-2 in Ha-rasoncogene induced apoptosis of NIH/3T3 cells. Seventh symposium on recent advances in cellular and molecular biology, 50, P36.
74. Lin, Y. L., Lei, H. Y., Yeh, T. M., Lin, Y. S., Liu C. C.and Liu, H. S. 1999. Pathogenic study of dengue-2 virus infected hepatocyte cell lines. Seventh symposium on recent advances in cellular and molecular biology, 50, P37.
75. Chang, T. Y. and Liu, H. S. 1998. A Plasmid harboring Lac repressor and Tet activator regulates two inducible genes in mammalian cells. The 32nd annual meeting of the Chinese society of microbiology. National Taiwan University. Taipei. Taiwan R.O.C., CSM-69.
76. Lin, Y. L., Lei, H. Y., Yeh, T. M., Lin, Y. S., Liu, C. C. and Liu, H. S. 1998. Pathogenic study of dengue-2 virus infected hepatocyte cell lines. The 32nd annual meeting of the Chinese society of microbiology. National Taiwan University. Taipei. Taiwan R.O.C., CSM-89.
77. Chou, C. K., and Liu, H. S. 1998. Study on apoptosis and colony formation of a NIH/3T3 derivative 7-4 containing an inducible Ha-ras oncogene. The thirteenth joint annual conference of biomedical science. National Taiwan University. Taipei. Taiwan. R. O. C., 147.
78. Chang, M. Y., Lee, C. H., Won, S. J., and Liu, H. S. 1998. Selective activation of Ha-rasval12 oncogene induces NIH/3T3 cell susceptibility to TNF-��. Sixth symposium on recent advances in cellular and molecular biology, 91, P89.
79. Lee, C. F., Chen, C. Y., Lee, C. H., Chou, Y. I., and Liu, H. S. 1998. Selective induction of Ha-rasval12 oncogene induced apoptosis in NIH/3T3 cells. Sixth symposium on recent advances in cellular and molecular biology, 91, P90.
80. Chou, C. Y., Shen, M. R., and Liu, H. S. 1997. The capacity of cell volume regulation is associated with extent of tumor potential in human cervical cells and Ha-ras transformed NIH3T3 cells. Proceedings of the American Association for Cancer Research. 38, 61.
81. Lin, Y. L., and Liu. H. S. 1997. Pathogenic study on five hepatoma cell lines after dengue-2 virus infection. The 31st annual meeting of the Chinese Society of Microbiology. National Taiwan University. Taipei. Taiwan. R. O. C., CSM-63, V31.
82. Liu, H. S., and Lin, Y. L. 1997. Construction of infectious full-length dengue-2 virus cDNA.97th General meeting, American Society for Microbiology, Miami Beach, U. S. A., 540, T24.
83. Chang, T. Y., and Liu, H. S. 1997. Demonstration of Tet and Lac double inducible gene regulation in many cell lines. The twelfth joint annual conference of biomedical science. National Taiwan University. Taipei. Taiwan. R. O. C., 173, 132.
84. Chang, M. Y., Won, S. J., and Liu, H. S. 1997. Effect of Ha-ras oncogene overexpression in NIH3T3 cell lines on the TNF-��n�ninduced cytotoxicity. The twelfth joint annual conference of biomedical sciences. National Taiwan University. Taipei. Taiwan. R. O. C.,144, 015.
85. Lee, C. H., and Liu, H. S. 1997. Study on Ha-ras induced apoptosis in NIH/3T3 cell lines. Fifth symposium on recent advances in cellular and molecular biology, 88, P40.
86. Chou, C. Y., Shen, M. R., and Liu, H. S. 1997. Differential capacity of cell volume regulation in human cervical and Ha-ras transformed NIH3T3 cells with different tumor potential. The FASEB J. 11, A513.
87. Lin, Y. L., and Liu, H. S. 1996. Construction infectious full-length dengue virus type 2 cDNA. The 30th annual meeting of the Chinese Society of Microbiology. National Taiwan University. Taipei. Taiwan. R. O. C., CSM-59, V18.
88. Liu, H. S. 1996. Application of an inducible Ha-ras oncogene in NIH/3T3 cell lines. NHRI Symposium on Cancer. Ta-Si, Tau-Yuan,15, A8.
89. Chang, M. Y., Liu, H. S., and Won, S. J. 1996. A ribozyme specifically suppress Ha-ras oncogene induced transformation and tumorigenicity of the transformed NIH/3T3 cells. The Eleventh Joint Annual Conference of Biomedical Sciences. National Taiwan University. Taipei. Taiwan. R.O.C., 96, 064.
90. Chou, Y. I., Chen, C. Y., and Liu, H. S. 1996. Effect of the inducible Ha-rasoncogene expression on the apoptosis of a transformed NIH/3T3 fibroblast cell line. The Eleventh Joint Annual Conference of Biomedical Sciences. Taipei. Taiwan. R.O.C., 123, 170.
91. Chou, Y. I., Chen, C. Y., and Liu, H. S. 1996. An inducible Ha-ras Oncogene induced apoptosis in a NIH/3T3 fibroblast cell line. Fourth Symposium on Recent Advances in Cellular and Molecular Biology. National Taiwan University. Taipei. Taiwan. R.O.C., 23, A4.
92. Lin, Y. L., Chen, C. C., and Liu, H. S. 1995. The kinetics of dengue-2 virus sense, antisense, RI and RF RNA synthesis in mosquito AP-61 and mammalian BHK-21 cells. The 29th Annual meeting of the Chinese Society of Microbiology, National Taiwan University, Taipei, Taiwan, R.O.C., 115, V14.
93. Liu, H. S., Tzeng, H. C., Liang, Y. J., and Chen, C.C. 1994, Construction of the full length cDNA of dengue-2 virus. 94rd ASM general meeting,. Las Vegas, Nevada., 490
94. Tasi, W. C., and Liu, H. S. 1994. The effect of Ha-ras oncogene on colony formation of transformed NIH3T3 cells in soft agar. The 28th Annual Meeting of the Chinese Society of Microbiology, National Taiwan University, Taipei, Taiwan, R. O. C., 68.
95. Liu, H. S. 1993. PCR 在醫學診斷及刑事科學之應“DNA聚合酶連鎖反應之應” 研習會, National Chung Sun University, Kaushung, Taiwan, R. O. C. , 43-49.
96. Liu, H. S. 1993. An inducible Ha-ras Oncogene induced apoptosis in a NIH/3T3 fibroblast cell line. First Symposium on Recent Advances in Cellular and Molecular Biology. 墾丁, 恆春, P53.
97. Liu, H. S., Chang, T. Y. and Chen, C.C. 1993. Detection of dengue-2 virus by northern blotting and in situ hybridization using a radioactive and non-radioactive exchangeable labeling system. 93rd ASM general meeting, 440.
98. Lin, Y. L., Chen, C. C., and Liu, H. S. 1993. The kinetics of dengue-2 virus RNA synthesis in AP-61 cells by RT-PCR. The 27th Annual meeting of the Chinese Society of Microbiology, Chang Gung college of Medicine, Tao-Yuan, Taiwan, R. O. C. , 68.
99. Tzeng, H. C., and Liu, H. S. 1993. Comparison of Ha-ras transformed NIH3T3 cell lines with repressors harboring NLS at different locations. The 27th Annual meeting of the Chinese Society of Microbiology, Chang Gung college of Medicine, Tao-Yuan, Taiwan, R. O. C. , 68.
100. Liu, H. S. 1992. SV40 early promoter drives gene expression under the regulation of bacterial regulatory elements. Workshop on the establishment of mammalian cell lines by transformation with temperature-sensitive SV40, National Taiwan University, Taipei, Taiwan, R. O. C. , 10.
101. Liu, H. S., Chang, T. Y. and Chen, C.C. 1992. Development of non-radioactive probes for the detection of dengue-2 virus. Arboviruses Conference, National Defense Medical Center, Taipei, Taiwan, R. O. C., 58.
102. Liu, H. S., Lieberman, M. A., and Stambrook, P. J. 1991. Transformation of NIH 3T3 cells can be controlled by bacterial regulatory elements. J. Cell Biol. 115, 306a.
榮譽與獎勵
發明專利
1. 林忠男，翁舷誌，劉校生，劉崇喜，1993‑2013，一種新奇妙腫瘤之黃環酮化物 ,日本專利，專利號碼特許久第255444號.
2. 林忠男，翁舷誌，劉校生，劉崇喜，1998-2015，台產新靈芝等相關藥用資源 合成Xanthones抗癌物質之開發研究，美國專利，專利權號數:發明第5741813號
3. 林忠男，翁舷誌，劉校生，劉崇喜，1999‑2017，台產新日本靈芝等相關藥用資源及合成Xanthones之抗癌物質之開發研究，美國專利，專利權號數:發明第 5981774號。
邀請演講
1. Liu, H. S. 2012. Autophagy, virus, microRNA and tumorigenesis. Vaccine research & Development Center, National Health Research Institutes. (5-2-2012) (Invited Speech)
2. Liu, H. S. , Wu, S. Y., Lan, S. H. 2011. Characterization of miR-224 and its involvement in autophagy and tumorigenesis. 2011 International Symposium on cell signaling and Gene regulation. Feb. 19-20, 2011. NCKU, Tainan, Taiwan. P11 (Invited Speech)
3. Liu, H. S., Wu C. H., Tseng, Y. S. and Sheu H. M. 2010. Transcriptional regulation of Aurora-A activation by low dosage arsenic in the immortalized skin cell lines. 2010 Workshop for EU FP7 cooking project sponsored by NSC. Dec. 13-15, 2010.Department of Earth Sciences, National Cheng Kung University, Tainan, Taiwan. P16. (Invited Speech)
4. Liu, H. S. 2010. Enterovirus 71 induced autophagy and its role in pathogenesis. Symposium on Receptor, Immunopathogenesis, and Thearpy of Enterovirus 71 Infection. NHRI building, National Cheng Kung University, Tainan, Taiwan. Oct. 9, 2010. (Invited Speech)
5. Liu, H. S. 2010. Biomarkers of esophageal cell carcinoma invasion and metastasis related microRNAs and target genes (食道癌入侵及轉移相關之MicroRNA及其目標基因生物標記之探討) 台灣基因醫學暨生物標記學會成立大會.Sept. 18, 2010. 高雄夢時代廣場。 (Invited Speech)
6. Liu, H. S. 2010. Enterovirus 71 induced autophagy and its role in pathogenesis. BIT’s 1st World Congress of Virus and Infections-2010. Theme: Voice of Virologists. July 31-August 3, 2010. p095 (Invited Speech)
7. Liu, H. S. The role of autophagy in cancer and virus replication. Department of Biomedical Sciences, Chung Shan Medical University. Jan. 4th, 2010.
8. Liu, H. S. , Lee, Y. R., Wang, P. S., and Hu, H. Y. 2009. In vitro and in vivostudy of dengue virus type 2 and enterovirus 71 induced autophagy. Indo-Taiwanese workshop on infectious diseases. Indian Institute of Science, Bangalore, India. Nov. 27-28, 2009, P10.
9. Liu, H. S. 2009. Ha-ras oncogene induces autophagy and its role in tumorigenesis. BIT Life Sciences’ 2nd Annual World Cancer Congress-2009. Beijing International Convention Center (BITC), Beijing, China. June 22-25, 2009. (Invited Speech)
10. Kao Yu-Ting (高毓婷), Wu Chin-Han (吳金漢), and Liu, H. S. 2009. In vitro and in vivo study of dosage and time effect of arsenic treatment on Aurora-A over-expression in bladder tumorigenesis. 國立 成功大學地球科學系專題演講. June 12, 2009.
11. Liu, H. S., Lee, Y. R., and Shih, S. M. 2008. Autophagy induced by dengue virus type 2 and its role in immunopathogenesis. The second international conference on dengue and dengue haemorrhagic fever “Global Innovation to fight dengue”15-17 October 2008, Phuket, Thailand.
12. Liu, H. S., Wu, S. Y., and Lan, S. H. 2008. The mechanism of Ha-rasval12 induced autophagy. BIT Life Sciences’ 1st Annual World Cancer Congress-2008. Everbright Convention & Exhibition Center, Shanghai, China. June 12-15, 2008.
13. Liu, H. S. 2008. The mechanism of Arsenic exposure induced Aurora-A overexpression in the bladder cancer cell line E7. 2008 International workshop on arsenic and humic substances and their health effects. May 13-14, 2008, National Cheng Kung University, Tainan
14. Liu, H. S. 2007. Autophagy and its role in dengue virus and enterovirus replication.嘉義大學微生物及免疫學研究所
15. Liu, H. S. 2004. The application of bioinformatics in bladder cancer progression. 嘉南技大學生物科技研究所
16. Liu, H. S. 2004. The application of bioinformatics in cancer. 高雄醫學大學基因體中心
17. Liu, H. S. 2004. Signal transduction of a ras up-regulated gene Lutheran in human bladder carcinogenesis. 中山大學基因調控與訊息傳遞新知研討會.
18. Liu, H. S. 2003. The quest for molecular signatures of bladder cancer progression. 南台科技大學功能性基因體學研討會
19. Liu, H. S. 2003. The quest for molecular signatures of bladder cancer progression. 國立陽明大學生物資訊學程
20. Liu, H. S., Chow, N. H., Chiang, J. H., Tseng, S. M., and Ho, C. L. 2003. Innovative approach for molecular signatures of bladder carcinoma. Eleventh symposium on recent advances in cellular and molecular biology. 墾丁, 恆春 , P37.
21. Liu, H. S., Shen, H. C., and Chow, N. H., 2002. Antiapoptotic effect of c-metin bladder cancer cells. Symposium on tissue remodeling: Growth, apoptosis, and differentiation. National Cheng Kung University, Oct. 21-22, Tainan, Taiwan, S9.
22. Liu, H. S. 2003. Development of cancer related diagnosis microarray chips in Cheng Kung University Medical Center. 首屆海峽兩岸科技與經濟論談, 福州, 福建.
23. Tseng, Y. S., Huang, C. Y., and Liu, H. S. 2001. Synergistic activation of transcription factor Elk by Ras and Aurora-A. Symposium on cell signaling and gene expression. International conference center Kobe, Japan, p17.
24. Liu, H. S. 2001. The relationship between dengue virus and host cells. NHRI conference on dengue virus and dengue fever. Aspire learning complex, Tao-Yuan, Taiwan, p10.
25. Liu, H. S., Shen, H. C., and Chow, N. H. 2001. Signal transduction of c-metoverexpression in bladder carcinoma. NHRI conference on signal transduction, Aspire learning complex, Tao-Yuan, Taiwan, p20.
26. Liu, H. S. 2000. A cell culture system for anticancer drug screening. 中國醫藥學院中醫學研究所.
27. Liu, H. S. 2000. Ha-ras oncogene induced apoptosis. 台中榮民總醫院.
28. Liu, H. S. 2000. Application of an inducible Ha-ras oncogene in anticancer drug screening using NIH/3T3 cell lines. NHRI, 分子與醫學研究組.
29. Liu, H. S. 1999. Ha-ras oncogene and apoptosis. 細胞凋亡研討會，台北榮民總醫 院. p7.
30. Liu, H. S. 1996. Application of an inducible Ha-ras oncogene in NIH/3T3 cell lines. NHRI Symposium on Cancer. Ta-Si, Tau-Yuan,15, A8.
31. Liu, H. S. 1993. PCR在醫學診斷及刑事科學之應“DNA聚合酵素連鎖反應之應” 研習會, National Chung Sun University, Kaushung, Taiwan, R. O. C. , 43-49.
32. Liu, H. S. 1993. An inducible Ha-ras Oncogene induced apoptosis in a NIH/3T3 fibroblast cell line. First Symposium on Recent Advances in Cellular and Molecular Biology. 墾丁, 恆春, P53.
33. Liu, H. S. 1992. SV40 early promoter drives gene expression under the regulation of bacterial regulatory elements. Workshop on the establishment of mammalian cell lines by transformation with temperature-sensitive SV40, National Taiwan University, Taipei, Taiwan, R. O. C. p10.
舉辦研討會
1. 如何將生物資訊學應用於癌症之研究研討會 Liu, H. S., Lin, Y. P., Chang, T. Y., Shin, J. W., Tseng, S. M., Chiang, J. S., Chan, S. H., Chow, N. H., and Ho, C. L. January 15th, 2005. “The application of bioinformatics in cancer research “conference held in Medical center, National Cheng Kung University, Tainan.
2. Parasitic Zoonoses in Asian-Pacific Regions September 3-4, 2004, held in College of Medicine, National Cheng Kung University, Tainan, Taiwan.
歷年指導大學生與研究生之獲獎紀錄
1994 指導醫技三陳炳宏參加醫學院暑期研究論文比賽榮獲第一名
1995 指導醫技四陳炳宏參加第六屆全校論文比賽榮獲特優獎
1995 獲頒校長熱心教育獎
1995 指導醫學三周言穎參加醫學院暑期研究論文比賽獲第一名
1996 指導醫學四周言穎參加第七屆全校論文比賽獲特優獎
1996 獲頒校長熱心教育獎
1997 指導醫技三柯妮妗參加醫學院暑期研究論文比賽獲第三名
2002 指導微免碩二李英瑞參加第三十六屆中華民國微生物學會海報論文比賽獲病毒組第二名
2003 指導博三葉宣亨參加92年基醫所研究日海報論文比賽優勝
2004 指導博二李英瑞參加第三十八屆中華民國微生物學會海報論文比賽獲病毒組第二名
2004 指導生科三陳偉愷參加國科會暑期研究論文比賽獲優等獎
2005 指導博三李英瑞參加第二十屆中華民國生物醫學聯合學術年會優良看板論文壁報獎
2006 指導李秀儀第十四屆細胞及分子生物新知研討會研究生論文競賽優勝
2006 指導葉宣亨九十四年度基礎醫學博士班學生研究口頭發表競賽優勝
2007 指導李英瑞第十五屆細胞及分子生物新知研討會研究生論文競賽優勝
2008 指導碩二高毓婷參加九十七年度微免所研究生海報論文比賽優勝
2008 指導博二吳珊瑩、藍昇輝參加細胞訊息及基因調控國際研討會看板論文競賽優勝
2008 指導史杏枚參加第 四十二屆中華民國微生物學會海報論文比賽病毒組第一名
2008 指導碩二王伯舜參加第四十二屆中華民國微生物學會海報論文比賽病毒組第二名
2009 指導碩二高毓婷參加九十七年度微免所研究生口頭論文發表競賽優勝
2009 指導碩二高毓婷參加九十七年度醫學院碩士班學生研究口頭發表競賽第一名
2009 指導史杏枚參加第四十三屆中華民國微生物學會海報論文比賽病毒組第二名
2009 指導碩二王伯舜參加第第二十四屆生物醫學聯合學術年會獲優秀看板論文壁報獎
2009 指導醫學三王吳孟珊參加醫學院暑期研究論文海報比賽獲第一名
2010 指導醫學三王恩浩參加醫學院暑期研究論文比賽獲第一名
2010 指導碩二胡瑄耘參加第四十四屆中華民國微生物學會海報論文比賽病毒組研究論文比賽獲第一名
2011 指導博五藍昇輝參加般2011年International Symposium on Infectious disease and Signal Transduction & Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation.海報論文比賽優勝獲第一名
校內外研究團隊主持、本校研究、教學傑出
1. 成大醫學院核心實驗室主持人2010迄今
2. 成大醫學院 2009迄今年公用儀器委員會召集人
3. 2009年教學優良教師
4. 成大醫學院核心實驗室〝成大晶片中心〞之主持人 (2004~迄今)
5. 曾擔任微生物及免疫學研究所所長並兼任寄生蟲學科主任
(2003-8-1~2006-7-31) 。
6. 曾擔任跨領域計畫總主持人(NSC: 93-2321-B-006-009; 2002-8-1~2004-12-31)計畫名稱: 以生物資訊方法搜尋砷相關膀胱癌之表現型錄及確認新穎之指標因子。
7. 曾擔任永續型群體計畫總主持人(NSC: 95-2621-Z-006-009; 2006-8-1~2007-7-31) 計畫名稱: 以公共衛生及毒理觀點進行砷的致癌性之基礎與應用研究。
8. 2008-2010 擔任生物資訊與訊息傳遞研究所教評會委
9. 2010-2012 擔任醫事技術研究所教評會委員
國際合作
1. 與法國之國家醫學院及衛生研究院( INSERM)細胞模式實驗室之Dr. M. J. Marion 合作篩選TGF-β誘發肝細胞進行上皮-間質(ETM)轉化與Ras以及Tyrosine kinase相關之新穎基因，以做為長期研究發展之用。
2. 與中國大陸南京大學生命科學院醫藥生物技術國家重點實驗室甘黛蒂副教授進行金銀花茶誘發體內microRNA抑制病毒以及抗癌之研究。