小檔案

學歷

日本京都府立醫科大學微生學博士 (1980)

經歷

成功大學微免所教授 (1990-2006)

成功大學微免所所長 (1988-1994)

專長學門

抗癌及抗病毒藥物之研發; 細胞素誘導物之研究

研究興趣

抗癌藥物及抗病毒的研發，並就這些具有藥效之藥物進行人工合成及研究其作用機轉。

熱中風與 Cytokines 及細胞免疫之關係。

細菌或病毒感染（或其產物）所引發之發炎反應研究：探討腦中 cytokine產生及其基因表現在發炎生成中所扮演之角色。

環境溫度與藥物對細胞免疫之影響評估。

PUBLICATIONS

歷年論文發表

1.      Su, C. L., Lin ,T. Y., Lin, C. N., and Won, S. J.: Involvement of Caspases and apoptosis-inducing factor in Bufotalin-induced apoptosis of Hep 3B. J. Agric. Food Chem. 57: 55–61, 2009.

2.      Lee, J. C., Su, C. Li., Chen, L. L., and Won, S. J.: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 100: 503–513, 2008.

3.      Cheng, J. H., Hung, C. F., Yang, S. C., Wang, J. P., Won, S. J., and Lin, C. N.: Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 20,50-dialkoxylchalcones as cancer chemopreventive agents. Bioorgan. Med. Chem. 16: 7270-7278, 2008.

4.      Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., Ling, P., Lin, C. N., and Su, C. L.: Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. BBRC 372: 236-242, 2008.

5.      Wu, C. C., Lu, Y. H., Wei, B. L., Yang, S. C., Won, S. J., and Lin, C. N. Phloroglucinols with Prooxidant Activity from Garcinia subelliptica.: J. Nat. Prod. 71: 246–250, 2008

6.      Su, C. L., Lin, M. T., Cheng, C. C., Yeh, H. C., Lee, J. Ch., Lee, M. C., and Won, S. J.: NADPH oxidase and NF-kB regulate staphylococcal enterotoxin C1 induced-pyrogenic cytokine production in human peripheral blood mononuclear cells. FEBS J. 274: 3633-3645, 2007.

7.      Wei, B. L ,, Teng, C. H., Wang, J. P., Won, S. J., and Lin, C. N.: Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages. Eur. J. Med. Chem. 42:660-668, 2007.

8.      Su, C. Li., Wu, C. J. Chen, F. N., Wang, B. J., Sheu, S. R., and Won, S. J.: Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria. Food Chem. Toxicol. 45: 303–314, 2007

9.      Su, C. Li., Huang, L. L.H., Huang, L. M., Lee, J. C., Lin, C. N., and Won, S. J.: Caspase 8 acts as a key upstream of mitochondria during justicidin A-induced apoptosis in human hepatoma cells. FEBS Letters 3185-3191, 2006.

10.  Lee, J. C., Lee, C. H., Su, C. L., Huang, C. W., Liu, H. S., Lin, C. N., and Won, S. J.: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis 26: 1716-1730, 2005.

11.  Wang, B. J., Won, S. J., Yu, Z. R., and, Su, C. L.: Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. Food Chem. Toxicol. 43: 543–552, 2005.

12.  Won, S. J., Liu, C. T., Tsao, L. T., Weng, J. R. Ko, H. H., Wang, J. P., and Lin, C. N.: Synthetic chalcones as potential anti-inflammatory and caner chemopreventive agents. Eur. J. Med. Chem. 40: 103-112, 2005.

13.  Teng, C. H., Won, S. J., and Lin, C. N.: Design. Synthesis and cytotoxic effect of hydroxyl- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives. Bioorg. Med. Chem. 13: 3439-3445, 2005.

14.  Wu, C. C., Weng, J. R., Won, S. J. and Lin, C. N.: Constituents of the pericarp of Garcinia subelliptica. J. Nat. Prod. 68: 1125 -1127, 2005.

15.  Ko, H. H., Lu ,Y. H., Yang, S. Z., Won, S. J. and Lin, C. N.: Cytotoxic Prenylflavonoids from Artocarpus elasticus. J. Nat. Prod. 68, 1692-1695, 2005.

16.  Wang L. W., Su, H. J., Yang, S. Z., Won, S. J., and Lin C. N.: New alkaloids and a tetraflavonoid from Cephalotaxus wilsoniana. J. Nat. Prod. 67:1182-5, 2004.

17.  Su, H. J., Wang, L. W., Lin, C. N., Day, S. H., Wei, B. L., Yang, S. Z., and Won, S. J.: A diterpenoid with a new skeleton and cytotoxic terpenoids isolated from Amenotaxus formosana. Helv. Chim. ACTA. 86: 2645-2652, 2003.

18.  Tseng, Y. S., Tzeng, C. C., Chiu, A. W. S., Lin, C. H., Won, S, J., Wu, I. C., Liu, H. S.: Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil. Exp. Cell Res. 288: 403-414, 2003.

19.  Day, S. H., Lin, Y. C., Tsai, M. L., Tsao, L. T., Ko, H. H., Chung, M. I., Lee, J. C., Wang, J. P., Won, S. J., and Lin, C. N.: Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. J. Nat. Prod. 65:379-381, 2002.

20.  Day, S. H., Wang, J. P., Won, S. J., and Lin, C. N.: Bioactive constituents of the roots of Cynanchum atratum. J. Nat. Prod. 64: 608-11, 2001.

21.  Tsai, Y. C., and Won, S. J.: Effects of tramadol on T lymphocyte proliferation and natural killer cell activity in rats with sciatic constriction injury. Pain 92: 63-69, 2001.

22.  Tsai, Y. C., Won, S. J., and Lin, M. T.: Effects of morphine on immune response in rats with sciatic constriction injury. Pain 88:155-160, 2000.

23.  Chung, M. I., Wu, S. H., Won, S. J., Tsao, L. T. Wang, J. P., and Lin, C. N.: Synthesis and cytotoxic effect of 1,3-dihydroxy-9,10-anthraquinone derivatives. Eur. J. Med. Chem. 35: 1089-1098, 2000.

24.  Won, S. J., Huang, W. T., Lai, Y. S., and Lin, M. T.: Staphylococcal enterotoxin A acts through nitric oxide synthase mechanisms in human peripheral blood mononuclear cells to stimulate synthesis of pyrogenic cytokines. Infect. Immun. 68: 2003-2008, 2000.

25.  Su, H. J., Fann, Y. F., Chung, M. I., Won, S. J., and Lin, C. N.: New lanostanoids of Ganoderma tsugae. J. Nat. Prod. 60: 514-516, 2000.

26.  Ko, H. H., Yen, M. H., Wu, R. R., Won, S. J., and Lin, C. N.: Cytotoxic isoprenylated flavans of Broussonetia Kazinoki. J. Natl. Prod. 62: 164-166, 1999.

27.  Chang, M. Y., Won, S. J., Yang, B. C., Jan, M. S. and Liu, H. S.: Selective activation of Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to TNF-a. Exp. Cell Res. 248: 589-598, 1999.

28.  Day, S. H., Chiu, N. Y., Won, S. J., and Lin, C. N.: Cytotoxic lignans of Justicia ciliata. J. Nat. Prod. 62: 164-166, 1999.

29.  Won, S. J., Huang, H. F., and Lin, M. T.: Heatstroke induces a reduction of natural killer cell activity in rats. J. Therm. Biol. 24: 447-453, 1999.

30.  Huang, P. L., Won, S. J., Day, S. H., and Lin, C. N.: A cytotoxic acetophenone with a novel skeleton, isolated from Cynanchum taiwanianum. Helvet. Chim. ACTA 82: 1-5, 1999.

31.  Chang, M. Y., Jan M. S., Won, S. J., and Liu, H. S.: Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin. Bioch. Bioph. Res. Com. 248: 62-68, 1998.

32.  Chang, M. Y., Won, S. J., and Liu, H.S.: A ribozyme specifically suppresses transformation and tumorigenicity of Ha-ras-oncogene-transformed NIH/3T3 cell lines. J. Cancer Res. Oncol. 123: 91-99, 1997.

33.  Liu, H. S., Lin, C. N., and Won, S. J.: Antitumor effect of 2,6-di(2,3-epoxyprpoxy)xanthone on tumor cell lines. Anticancer Res. 17:1107-1114, 1997.

34.  Huang, W. T., Lin, M. T., and Won, S. J.: Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits. Neurosci. Lett. 236: 53-56, 1997.

35.  Huang, W. T., Lin, M. T., and Won. S. J.: Staphylococcal enterotoxin A induced fever: Possible involvement of cyclo-oxygenase and protein synthesis mechanisms in rabbitts. Infect. Immun. 65:2656-2662, 1997.

36.  Lin, C. N., Liou, S. J., Lee, T. H., Chuang, Y. C., and Won, S. J.: Xanthone derivatives as potential anti-cancer drugs. J. Pharm. Pharmacol. 48: 539-544, 1996.

37.  Won, S. J., Yang, B. C., and Lin, M. T.: Thermal stresses increase splenic phosphorylation and reduce natural killer cell cytotoxicity. J. Appl. Physiol. 79:732-737, 1995.

38.  Won, S. J., Chuang, Y. C., Huang, W. T., Liu, H. S., and Lin, M.T.: Suppression of natural killer cell activity by several dopamine receptor antagonists. Experientia 51:343-348, 1995.

39.  Can, K. H., Lin, C. N., and Won. S. J.: Cytotoxic principles and their derivatives of Formosan solanum plants. J. Nat. Prod. 56: 15-21, 1993.

40.  Lin, C. N., Shieh, W. L., Lieu, S. S., Cheng, T. H., and Won. S. J.: g-pyrone compounds as potential anti-cancer drugs. J. Pharm. Pharmacol. 45: 791-794, 1993.

41.  Won. S. J., and Lin, M. T.: Endogenous pyrogen formation by human blood monocytes stimulated by polyriboinosinic acid:polyribocytidylic acid. Experientia 49: 157-159, 1993

42.  Won, S. J., and Lin, M. T.: Alpha-methyl-p-tyrosine inhibits the augmenting interferon production and splenic NK cell activity in mice injected with an interferon inducer, J. Pharmacol. 46: 332-340, 1993.

43.  Lin, C. N., Kuo, S. H., and Won, S. J.: Steroids of Formosan Ganoderma amboinense. Phytochemistry 32: 1549-1551, 1993.

44.  Won. S. J., Lin, M. T., and Wu, W. L.: Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice. Japan J. Pharmacol. 59: 171-176, 1992.

45.  Wei, B. L., Lin, C. N., and Won. S. J.: Nakahalene and cytotoxic principles of Formosan Rhamnus species. J. Nat. Prod. 55: 967-969, 1992.

46.  Won. S. J., Lin, M. T., Ko, Y. Il., and Chuang, J.: The fever induced by polyriboinosinic acid:polyribocytidylic acid is not related to interferon synthesis in the rabbit's hypothalamus. J. Interf. Res. 11: 165-169, 1991.

47.  Won. S. J., and Lin, M. T.: Polyadennylic'polyuridylic acid (poly A:U) : an extrinsically prostaglandin-dependent pyrogen. Naunyn-Schmiedeberg's Arch. Pharmacol. 343: 551-557, 1991.

48.  Lin, C. N., Tome, W. P., and Won, S. J.: Novel Cytotoxic principles of Formosan Ganoderma Lucidum. J. Nat. Prod. 54: 998-1002, 1991.

49.  Chuang, J., Lin, M. T., Chan, S. A. and Won. S. J.: Febrile effects of Poly I:C and interferon : Relationship to somatostatin in rat's hypothalamus. Flugers Arch. Fur. J. Physiol. 415: 606-610, 1990.

50.  Lin, C. N., Tome, W. P., and Won. S. J.: A lanostanoid of Formsan Ganoderma Lucidum. Phytochemistry 29: 673-675, 1990.

51.  Lin, C. N., Won. S. J., Lu, C. M., and Gan, K. H.: The cytotoxic principles of Solanum Incanum. J. Nat. Prod. 53(2): 513-516, 1990.

52.  Hsieh, T. L., Chou, Y. L., Wang, S. C., and Won, S. J.: The study of biocompatibility of metallic implants. J. Biomed. Engin. Soc. 10: 15-29, 1990.

53.  Lin, M. T., Won, S. J., Fan, L. J., and Chai, C. Y.: Paramedian Reticular nucleus: A thermolytic area in the rat's caudal medulla. Flugers Arch. Fur. J. Physiol. 417: 418-424, 1990.

54.  Won. S. J., and Lin M. T.: Depletion of catecholamine with alpha-methyl-p-tyrosine suppresses splenic NK cell activity. Int. J. Immunopharm. 11: 451-457, 1989.

55.  Lin, M. T., Wang, P. S., Chuang, J., Fan, L. J., and Won, S. J.: Cold stress or a pyrogenic substance elevates Thyrotropin-release hormone levels in the rat hypothalamus thermogenic reactions. Neuroendocrinology 50: 177-181, 1989.

56.  Won. S. J., and Lin M. T.: The hypothalamic somatostatin (SS) may mediate the fever produced by polyriboinosinic acid:polyribocytidylic acid (Poly I:C) in rabbits. Elsevier Science Publishers B.V. (Biomedical Division) Thermal physiology, pp421-425, 1989.

57.  Won. S. J., Lee, S. S., Ke, Y. H., and Lin, M. T.: Enhancement of splenic NK cytotoxic activity by extracts of Ganoderma Lucidum mycelium in mice. J. Biomed. Lab. Sci. 2: 201-213, 1989.

58.  Won. S. J., and Lin, M. T.: The pyrogenicity of interferon and its inducer in rabbits. Am. J. Physiol. 254: R499-R507, 1988.

59.  Won, S. J., and Lin, M. T.: 5-Hydroxytryptamine receptors in the hypothalamus mediate thermoregulatory responses in rabbits. Naunyn-Schmiedeberg' s Arch. Pharmacol. 338: 256-261, 1988.

60.  Low, T. L. K., Chang, M. C., Won. S. J., Shen, C. L.,Shin, J. C., and Lin, C. Y.: Thymic hormones: Isolation, distribution, structures properties and clinical applications. Asia Pacif. Commun. Bioch. 2: 33-46, 1988.

61.  Won. S. J., Huang, K. Y., Kind, P., Hung, Y. M., and Lin, M. T.: Effect of abrus agglutinin on natural cytotoxicity of peripheral lymphocytes from normal individuals and patients with nasopharyngeal carcinoma. Asia Pacif. J. Pharm. 3: 221-230, 1988.

62.  Won, S. J., Chiang H. C., Kan, W. S., and Lin, M. T.: Augmentation of Mouse Splenic NK cytotoxic activity by extracts of Physalis angulata L. J. Biomed. Lab. Sci. 1: 83-97, 1988.

63.  Won, S. J., Lin, M. T., Chuang, J., and Huang, K. Y.: Interferon produces hyperthermic responses in rats. Chin. J. Physiol. 30: 49-58, 1987.

64.  Lin, L. Y., Won. S. J., Cheng, H. Y., Cheng, C. F., and Tai, F. S.: Induction of interferon by Chinese herbs in mice. Medical Dig. (N.D.M.C.) 6: 33-39, 1985.

65.  Wu, W. C., Fann, J. H., Won. S. J., Lin, L. Y., and Ju, S. H.: Transfer of F'lac+ plasmid from Erwinia amylovora to Salmonella typhimurium, Salmonella anatum, and Shigella flexneri. Plant prot. Bull. 26: 181-199, 1984.

66.  Imanishi, J., Kita, M., Sugino, S., Won. S. .J., and Kishida, T.: Enhanced production of interferon in mice infected with Mycobacterium bovis BCG. Biken J. 24: 123-126, 1981.

67.  Imanishi, J., Matsubara, M., Won. S. J., Nomura, H., and Kishida, T.: Combined protective effects of interferon and interferon induction on Herpes simplex and Ectromelia virus infection in mice. Antimicrob. Agent Chem. 19: 922-924, 1981.

68.  Imanishi, J., Kita, M., Won. S. J., and Kishida, T.: Interferon (IFN) inducibility of Corynebacterium pawum and its effect on IFN production. Medicine and Biol. 103: 33-37, 1981.

69.  Imanishi, J., Nomura, H., Matsubara, M., Kita, M., Won. S. J. Mizutani, T., and Kishida, T.: Effect of polychlorinated bipheny on viral infections in mice. Infect. Immun. 29: 275-277, 1980.

70.  Imanishi, J., Won. S. J., Matsubara, M., Nomura, H., and Kishida, T.: Synergic effects of interferon and interferon inducer against Ectromelia virus infection in mice. Biken J. 23: 77-81, 1980.

71.  Won. S. J.: Comparative effect of interferon, its inducer and combination of both on Ectromelia virus infection in mice. J. Kyoto Pref. Univ. Med. 89: 87-99, 1980.

72.  Wu, W. C., and Won. S. J. : Transfer of F'lac+ plasmid from Salmonella typhimuriunz LT2 to a clinical strain of Salmonella anatum. China Medical College Annual Bulletin 10: 1-10, 1979.

73.  Wu, W. C., and Won. S. J.: Transfer of F'lac+ plasmid from Salmonella typhimurium to Shigella flexneri. Chinese J. Micro. 11: 141-143, 1978.

1.      Su, C. L., Lin ,T. Y., Lin, C. N., and Won, S. J.: Involvement of Caspases and apoptosis-inducing factor in Bufotalin-induced apoptosis of Hep 3B. J. Agric. Food Chem. 57: 55–61, 2009.

2.      Lee, J. C., Su, C. Li., Chen, L. L., and Won, S. J.: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 100: 503–513, 2008.

3.      Cheng, J. H., Hung, C. F., Yang, S. C., Wang, J. P., Won, S. J., and Lin, C. N.: Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 20,50-dialkoxylchalcones as cancer chemopreventive agents. Bioorgan. Med. Chem. 16: 7270-7278, 2008.

4.      Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., Ling, P., Lin, C. N., and Su, C. L.: Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. BBRC 372: 236-242, 2008.

5.      Wu, C. C., Lu, Y. H., Wei, B. L., Yang, S. C., Won, S. J., and Lin, C. N. Phloroglucinols with Prooxidant Activity from Garcinia subelliptica.: J. Nat. Prod. 71: 246–250, 2008

6.      Su, C. L., Lin, M. T., Cheng, C. C., Yeh, H. C., Lee, J. Ch., Lee, M. C., and Won, S. J.: NADPH oxidase and NF-kB regulate staphylococcal enterotoxin C1 induced-pyrogenic cytokine production in human peripheral blood mononuclear cells. FEBS J. 274: 3633-3645, 2007.

7.      Wei, B. L, Teng, C. H., Wang, J. P.,  Won, S. J., and Lin, C. N.: Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages. Eur. J. Med. Chem. 42:660-668, 2007.

8.      Su, C. Li., Wu, C. J. Chen, F. N., Wang, B. J., Sheu, S. R., and Won, S. J.: Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria. Food Chem. Toxicol. 45: 303–314, 2007

9.      Su, C. Li., Huang, L. L.H., Huang, L. M., Lee, J. C., Lin, C. N., and Won, S. J.: Caspase 8 acts as a key upstream of mitochondria during justicidin A-induced apoptosis in human hepatoma cells. FEBS Letters 3185-3191, 2006.

10.  Lee, J. C., Lee, C. H., Su, C. L., Huang, C. W., Liu, H. S., Lin, C. N., and Won, S. J.: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis 26: 1716-1730, 2005.

11.  Wang, B. J., Won, S. J., Yu, Z. R., and, Su, C. L.: Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. Food Chem. Toxicol. 43: 543–552, 2005.

12.  Won, S. J., Liu, C. T., Tsao, L. T., Weng, J. R. Ko, H. H., Wang, J. P., and Lin, C. N.: Synthetic chalcones as potential anti-inflammatory and caner chemopreventive agents. Eur. J. Med. Chem. 40: 103-112, 2005.

13.  Teng, C. H., Won, S. J., and Lin, C. N.: Design. Synthesis and cytotoxic effect of hydroxyl- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives. Bioorg. Med. Chem. 13: 3439-3445, 2005.

14.  Wu, C. C., Weng, J. R., Won, S. J. and Lin, C. N.: Constituents of the pericarp of Garcinia subelliptica. J. Nat. Prod. 68: 1125 -1127, 2005.

15.  Ko, H. H., Lu ,Y. H., Yang, S. Z., Won, S. J. and Lin, C. N.: Cytotoxic Prenylflavonoids from Artocarpus elasticus. J. Nat. Prod. 68, 1692-1695, 2005.

16.  Wang L. W., Su, H. J., Yang, S. Z., Won, S. J., and Lin C. N.: New alkaloids and a tetraflavonoid from Cephalotaxus wilsoniana. J. Nat. Prod. 67:1182-5, 2004.

17.  Su, H. J., Wang, L. W., Lin, C. N., Day, S. H., Wei, B. L., Yang, S. Z., and Won, S. J.: A diterpenoid with a new skeleton and cytotoxic terpenoids isolated from Amenotaxus formosana. Helv. Chim. ACTA. 86: 2645-2652, 2003.

18.  Tseng, Y. S., Tzeng, C. C., Chiu, A. W. S., Lin, C. H., Won, S, J., Wu, I. C., Liu, H. S.: Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil. Exp. Cell Res. 288: 403-414, 2003.

19.  Day, S. H., Lin, Y. C., Tsai, M. L., Tsao, L. T., Ko, H. H., Chung, M. I., Lee, J. C., Wang, J. P., Won, S. J., and Lin, C. N.: Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. J. Nat. Prod. 65:379-381, 2002.

20.  Day, S. H., Wang, J. P., Won, S. J., and Lin, C. N.: Bioactive constituents of the roots of Cynanchum atratum. J. Nat. Prod. 64: 608-11, 2001.

21.  Tsai, Y. C., and Won, S. J.: Effects of tramadol on T lymphocyte proliferation and natural killer cell activity in rats with sciatic constriction injury. Pain 92: 63-69, 2001.

22.  Tsai, Y. C., Won, S. J., and Lin, M. T.: Effects of morphine on immune response in rats with sciatic constriction injury. Pain 88:155-160, 2000.

23.  Chung, M. I., Wu, S. H., Won, S. J., Tsao, L. T. Wang, J. P., and Lin, C. N.: Synthesis and cytotoxic effect of 1,3-dihydroxy-9,10-anthraquinone derivatives. Eur. J. Med. Chem. 35: 1089-1098, 2000.

24.  Won, S. J., Huang, W. T., Lai, Y. S., and Lin, M. T.: Staphylococcal enterotoxin A acts through nitric oxide synthase mechanisms in human peripheral blood mononuclear cells to stimulate synthesis of pyrogenic cytokines. Infect. Immun. 68: 2003-2008, 2000.

25.  Su, H. J., Fann, Y. F., Chung, M. I., Won, S. J., and Lin, C. N.: New lanostanoids of Ganoderma tsugae. J. Nat. Prod. 60: 514-516, 2000.

26.  Ko, H. H., Yen, M. H., Wu, R. R., Won, S. J., and Lin, C. N.: Cytotoxic isoprenylated flavans of Broussonetia Kazinoki. J. Natl. Prod. 62: 164-166, 1999.

27.  Chang, M. Y., Won, S. J., Yang, B. C., Jan, M. S. and Liu, H. S.: Selective activation of Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to TNF-a. Exp. Cell Res. 248: 589-598, 1999.

28.  Day, S. H., Chiu, N. Y., Won, S. J., and Lin, C. N.: Cytotoxic lignans of Justicia ciliata. J. Nat. Prod. 62: 164-166, 1999.

29.  Won, S. J., Huang, H. F., and Lin, M. T.: Heatstroke induces a reduction of natural killer cell activity in rats. J. Therm. Biol. 24: 447-453, 1999.

30.  Huang, P. L., Won, S. J., Day, S. H., and Lin, C. N.: A cytotoxic acetophenone with a novel skeleton, isolated from Cynanchum taiwanianum. Helvet. Chim. ACTA 82: 1-5, 1999.

31.  Chang, M. Y., Jan M. S., Won, S. J., and Liu, H. S.: Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin. Bioch. Bioph. Res. Com. 248: 62-68, 1998.

32.  Chang, M. Y., Won, S. J., and Liu, H.S.: A ribozyme specifically suppresses transformation and tumorigenicity of Ha-ras-oncogene-transformed NIH/3T3 cell lines. J. Cancer Res. Oncol. 123: 91-99, 1997.

33.  Liu, H. S., Lin, C. N., and Won, S. J.: Antitumor effect of 2,6-di(2,3-epoxyprpoxy)xanthone on tumor cell lines. Anticancer Res. 17:1107-1114, 1997.

34.  Huang, W. T., Lin, M. T., and Won, S. J.: Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits. Neurosci. Lett. 236: 53-56, 1997.

35.  Huang, W. T., Lin, M. T., and Won. S. J.: Staphylococcal enterotoxin A induced fever: Possible involvement of cyclo-oxygenase and protein synthesis mechanisms in rabbitts. Infect. Immun. 65:2656-2662, 1997.

36.  Lin, C. N., Liou, S. J., Lee, T. H., Chuang, Y. C., and Won, S. J.: Xanthone derivatives as potential anti-cancer drugs. J. Pharm. Pharmacol. 48: 539-544, 1996.

37.  Won, S. J., Yang, B. C., and Lin, M. T.: Thermal stresses increase splenic phosphorylation and reduce natural killer cell cytotoxicity. J. Appl. Physiol. 79:732-737, 1995.

38.  Won, S. J., Chuang, Y. C., Huang, W. T., Liu, H. S., and Lin, M.T.: Suppression of natural killer cell activity by several dopamine receptor antagonists. Experientia 51:343-348, 1995.

39.  Can, K. H., Lin, C. N., and Won. S. J.: Cytotoxic principles and their derivatives of Formosan solanum plants. J. Nat. Prod. 56: 15-21, 1993.

40.  Lin, C. N., Shieh, W. L., Lieu, S. S., Cheng, T. H., and Won. S. J.: g-pyrone compounds as potential anti-cancer drugs. J. Pharm. Pharmacol. 45: 791-794, 1993.

41.  Won. S. J., and Lin, M. T.: Endogenous pyrogen formation by human blood monocytes stimulated by polyriboinosinic acid:polyribocytidylic acid. Experientia 49: 157-159, 1993

42.  Won, S. J., and Lin, M. T.: Alpha-methyl-p-tyrosine inhibits the augmenting interferon production and splenic NK cell activity in mice injected with an interferon inducer, J. Pharmacol. 46: 332-340, 1993.

43.  Lin, C. N., Kuo, S. H., and Won, S. J.: Steroids of Formosan Ganoderma amboinense. Phytochemistry 32: 1549-1551, 1993.

44.  Won. S. J., Lin, M. T., and Wu, W. L.: Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice. Japan J. Pharmacol. 59: 171-176, 1992.

45.  Wei, B. L., Lin, C. N., and Won. S. J.: Nakahalene and cytotoxic principles of Formosan Rhamnus species. J. Nat. Prod. 55: 967-969, 1992.

46.  Won. S. J., Lin, M. T., Ko, Y. Il., and Chuang, J.: The fever induced by polyriboinosinic acid:polyribocytidylic acid is not related to interferon synthesis in the rabbit's hypothalamus. J. Interf. Res. 11: 165-169, 1991.

47.  Won. S. J., and Lin, M. T.: Polyadennylic'polyuridylic acid (poly A:U) : an extrinsically prostaglandin-dependent pyrogen. Naunyn-Schmiedeberg's Arch. Pharmacol. 343: 551-557, 1991.

48.  Lin, C. N., Tome, W. P., and Won, S. J.: Novel Cytotoxic principles of Formosan Ganoderma Lucidum. J. Nat. Prod. 54: 998-1002, 1991.

49.  Chuang, J., Lin, M. T., Chan, S. A. and Won. S. J.: Febrile effects of Poly I:C and interferon : Relationship to somatostatin in rat's hypothalamus. Flugers Arch. Fur. J. Physiol. 415: 606-610, 1990.

50.  Lin, C. N., Tome, W. P., and Won. S. J.: A lanostanoid of Formsan Ganoderma Lucidum. Phytochemistry 29: 673-675, 1990.

51.  Lin, C. N., Won. S. J., Lu, C. M., and Gan, K. H.: The cytotoxic principles of Solanum Incanum. J. Nat. Prod. 53(2): 513-516, 1990.

52.  Hsieh, T. L., Chou, Y. L., Wang, S. C., and Won, S. J.: The study of biocompatibility of metallic implants. J. Biomed. Engin. Soc. 10: 15-29, 1990.

53.  Lin, M. T., Won, S. J., Fan, L. J., and Chai, C. Y.: Paramedian Reticular nucleus: A thermolytic area in the rat's caudal medulla. Flugers Arch. Fur. J. Physiol. 417: 418-424, 1990.

54.  Won. S. J., and Lin M. T.: Depletion of catecholamine with alpha-methyl-p-tyrosine suppresses splenic NK cell activity. Int. J. Immunopharm. 11: 451-457, 1989.

55.  Lin, M. T., Wang, P. S., Chuang, J., Fan, L. J., and Won, S. J.: Cold stress or a pyrogenic substance elevates Thyrotropin-release hormone levels in the rat hypothalamus thermogenic reactions. Neuroendocrinology 50: 177-181, 1989.

56.  Won. S. J., and Lin M. T.: The hypothalamic somatostatin (SS) may mediate the fever produced by polyriboinosinic acid:polyribocytidylic acid (Poly I:C) in rabbits. Elsevier Science Publishers B.V. (Biomedical Division) Thermal physiology, pp421-425, 1989.

57.  Won. S. J., Lee, S. S., Ke, Y. H., and Lin, M. T.: Enhancement of splenic NK cytotoxic activity by extracts of Ganoderma Lucidum mycelium in mice. J. Biomed. Lab. Sci. 2: 201-213, 1989.

58.  Won. S. J., and Lin, M. T.: The pyrogenicity of interferon and its inducer in rabbits. Am. J. Physiol. 254: R499-R507, 1988.

59.  Won, S. J., and Lin, M. T.: 5-Hydroxytryptamine receptors in the hypothalamus mediate thermoregulatory responses in rabbits. Naunyn-Schmiedeberg' s Arch. Pharmacol. 338: 256-261, 1988.

60.  Low, T. L. K., Chang, M. C., Won. S. J., Shen, C. L.,Shin, J. C., and Lin, C. Y.: Thymic hormones: Isolation, distribution, structures properties and clinical applications. Asia Pacif. Commun. Bioch. 2: 33-46, 1988.

61.  Won. S. J., Huang, K. Y., Kind, P., Hung, Y. M., and Lin, M. T.: Effect of abrus agglutinin on natural cytotoxicity of peripheral lymphocytes from normal individuals and patients with nasopharyngeal carcinoma. Asia Pacif. J. Pharm. 3: 221-230, 1988.

62.  Won, S. J., Chiang H. C., Kan, W. S., and Lin, M. T.: Augmentation of Mouse Splenic NK cytotoxic activity by extracts of Physalis angulata L. J. Biomed. Lab. Sci. 1: 83-97, 1988.

63.  Won, S. J., Lin, M. T., Chuang, J., and Huang, K. Y.: Interferon produces hyperthermic responses in rats. Chin. J. Physiol. 30: 49-58, 1987.

64.  Lin, L. Y., Won. S. J., Cheng, H. Y., Cheng, C. F., and Tai, F. S.: Induction of interferon by Chinese herbs in mice. Medical Dig. (N.D.M.C.) 6: 33-39, 1985.

65.  Wu, W. C., Fann, J. H., Won. S. J., Lin, L. Y., and Ju, S. H.: Transfer of F'lac+ plasmid from Erwinia amylovora to Salmonella typhimurium, Salmonella anatum, and Shigella flexneri. Plant prot. Bull. 26: 181-199, 1984.

66.  Imanishi, J., Kita, M., Sugino, S., Won. S. .J., and Kishida, T.: Enhanced production of interferon in mice infected with Mycobacterium bovis BCG. Biken J. 24: 123-126, 1981.

67.  Imanishi, J., Matsubara, M., Won. S. J., Nomura, H., and Kishida, T.: Combined protective effects of interferon and interferon induction on Herpes simplex and Ectromelia virus infection in mice. Antimicrob. Agent Chem. 19: 922-924, 1981.

68.  Imanishi, J., Kita, M., Won. S. J., and Kishida, T.: Interferon (IFN) inducibility of Corynebacterium pawum and its effect on IFN production. Medicine and Biol. 103: 33-37, 1981.

69.  Imanishi, J., Nomura, H., Matsubara, M., Kita, M., Won. S. J. Mizutani, T., and Kishida, T.: Effect of polychlorinated bipheny on viral infections in mice. Infect. Immun. 29: 275-277, 1980.

70.  Imanishi, J., Won. S. J., Matsubara, M., Nomura, H., and Kishida, T.: Synergic effects of interferon and interferon inducer against Ectromelia virus infection in mice. Biken J. 23: 77-81, 1980.

71.  Won. S. J.: Comparative effect of interferon, its inducer and combination of both on Ectromelia virus infection in mice. J. Kyoto Pref. Univ. Med. 89: 87-99, 1980.

72.  Wu, W. C., and Won. S. J. : Transfer of F'lac+ plasmid from Salmonella typhimuriunz LT2 to a clinical strain of Salmonella anatum. China Medical College Annual Bulletin 10: 1-10, 1979.

73.  Wu, W. C., and Won. S. J.: Transfer of F'lac+ plasmid from Salmonella typhimurium to Shigella flexneri. Chinese J. Micro. 11: 141-143, 1978.